Two New Phytoecdysteroids From Sphenocentrum jollyanum Pierre Root

Publication date: Available online 19 July 2019Source: SteroidsAuthor(s): Temitayo O. Ajayi, Radhakrishnan Srivedavyasasri, Emmanuel E. Nyong, Micheal A. Odeniyi, Jones O. Moody, Samir A RossAbstractThe crude methanol extract of Sphenocentrum jollyanum root exhibited 98% and 80% antimicrobial activity against Aspergillus fumigatus Pinh and Vancomycin resistant enterococcus (VRE) at a concentration of 200 µg/mL, with IC50 11.45 and 12.95 µg/mL, respectively. The ethyl acetate fraction of methanol extract showed in-vitro antimicrobial activity against A. fumigatus Pinh at 83% with IC50 of <8 µg/mL. The phytochemical investigation of ethyl acetate fraction yielded six compounds, which were identified by their NMR, IR and MS spectral analyses as two new phytoecdysteroidal glycosides Sphenocentroside A (1), and Sphenocentroside B (2), and four known phytoecdysteroids: polypodoaurein (3), polypodine B (4), ecdysterone (5), and 20, 26-dihydroxyecdysone (6).Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research