Glyconanoparticles for Targeted Tumor Therapy of Platinum Anticancer Drug.

Glyconanoparticles for Targeted Tumor Therapy of Platinum Anticancer Drug. Biomacromolecules. 2019 Jul 17;: Authors: Dag A, Omurtag Özgen PS, Atasoy S Abstract An important requirement to decrease the side effects of chemotherapy drugs is to develop nanocarriers with precise biological functions. In this work, a set of glyconanoparticles was prepared via self-assembly of amphiphilic glycoblock copolymers for the targeted delivery of a hydrophobic chemotherapy drug. Well-defined glycoblock copolymers that consist of 1,1-di-tert-butyl 3-(2-(metyloyloxy)ethyl)-butane-1,1,3-tricarboxylate (MAETC) together with three different protected-sugar moieties (β-D-glucopyranoside, β-D-mannopyranoside, and β-L-fucopyranoside) were synthesized by using RAFT polymerization. Copolymers were deprotected and conjugated with the cis-dichlorodiammineplatinum (II) (cis-Pt) anticancer drug. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements revealed that cis-Pt conjugated glyconanoparticles were sufficiently stable under physiological conditions and had diameters of approximately 100 nm with considerably narrow size distributions. They were intracellularly taken up by the breast cancer (MCF-7 and MDA-MB-231), prostate cancer (PC3), renal cancer (769-P) and Chinese hamster ovary (CHO) cell lines. PC3 and 769-P cell lines showed a high preference for the glycosylated nanoparticles. Glycoblock copolymers were found nont...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research