Cancers, Vol. 11, Pages 1011: Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
Cancers, Vol. 11, Pages 1011: Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
Cancers doi: 10.3390/cancers11071011
Authors:
Javier Menéndez-Menéndez
Francisco Hermida-Prado
Rocío Granda-Díaz
Alicia González
Juana María García-Pedrero
Nagore Del-Río-Ibisate
Alicia González-González
Samuel Cos
Carolina Alonso-González
Carlos Martínez-Campa
Melatonin mitigates cancer initiation, progression and metastasis through inhibition of both the synthesis of estrogens and the transcriptional activity of the estradiol-ER (Estrogen receptor) complex in the estrogen-dependent breast cancer cell line MCF-7. Moreover, melatonin improves the sensitivity of MCF-7 to chemotherapeutic agents and protects against their side effects. It has been described that melatonin potentiates the anti-proliferative effects of doxorubicin; however, the molecular changes involving gene expression and the activation/inhibition of intracellular signaling pathways remain largely unknown. Here we found that melatonin enhanced the anti-proliferative effect of doxorubicin in MCF-7 but not in MDA-MB-231 cells. Strikingly, doxorubicin treatment induced cell migration and invasion, and melatonin effectively counteracted these effects in MCF-7 but not in estrogen-independent MDA-MB-231 cells. Importantly, we describe for the first time the...
Source: Cancers - Category: Cancer & Oncology Authors: Javier Men éndez-Menéndez Francisco Hermida-Prado Roc ío Granda-Díaz Alicia Gonz ález Juana Mar ía García-Pedrero Nagore Del-R ío-Ibisate Alicia Gonz ález-González Samuel Cos Carolina Alonso-Gonz ález Carlos Mart ínez-Campa Tags: Article Source Type: research
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