Detectability of Breast Tumors in Excised Breast Tissues of Total Mastectomy by IR-UWB-Radar-Based Breast Cancer Detector

The objective of this paper is to investigate the detectability of breast tumors having various histological types in excised breast tissues of total mastectomy. The tumor images measured by a portable impulse-radio-ultra-wideband (IR-UWB)-radar-based breast cancer detector are compared with both pathological images and images of dedicated breast positron emission tomography. It is found that the detector can detect invasive-ductal-carcinomas and extensive intraductal component in the dense breast. The density of the breast has a correlation to the effective permittivity derived from the reconstructed confocal images. The results show that the IR-UWB-radar-based breast cancer detector has a potential as a portable modality for early-stage breast cancer screening.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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Abstract Squamous cell carcinoma is a rare histological type of breast cancer classified as metaplastic carcinoma. Metaplastic carcinoma involves differentiation of the breast glandular duct cells into mesenchymal tissues. While the chemotherapy regimen for metaplastic carcinoma is often similar to that for invasive ductal carcinoma, recurrence is associated with a poor prognosis due to the inadequate therapeutic efficacy of the regimen. We herein present the case of a 42-year-old female patient who underwent mastectomy of the right breast and right axillary node lymphadenectomy for T4N3aM0 breast cancer stage. Th...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
This study was designed to assess a novel gastrin releasing peptide receptor (GRPR) and integrin αvβ3 dual targeting PET/CT using 68Ga-BBN-RGD in patients with breast cancer and metastasis, and to evaluate the correlation between imaging quantification and immunohistochemical result of GRPR and integrin αvβ3 expression within primary and metastatic breast cancer lesions. Methods: A macrocyclic chelator, 1,4,7-triazacyclononane-N,N’,N"-triacetic acid (NOTA) conjugated BBN-RGD was synthesized and labeled with 68Ga. With ethics committee approval and written informed consent, 22 patients (F, a...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: First-in-Human & amp; New Human Applications Source Type: research
Author Affiliations open 1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA 2Social &Scientific Systems, Inc., Durham, North Carolina, USA 3Westat, Durham, North Carolina, USA 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway 5Biostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA PDF Version (548 KB) Abstract About This Article Supplemental Material Bac...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report a...
Source: Respectful Insolence - Category: Surgery Authors: Source Type: blogs
In conclusion, this combined metabolic approach appears effective in treating advanced TNBC, given this patient’s complete response with a good quality of life.Now, there is one thing that is interesting here. The doses of chemotherapy used were considerably lower thanwhat is usually used, with doses decreased by at least half or more. Does this mean anything? Who knows? cPR rates for TNBC have been reported to range from 20-35%. It could mean the regimen made the chemotherapy more effective, or it could mean that this woman just happened to have a particularly chemosensitive tumor. Even if we take this case report a...
Source: Respectful Insolence - Category: Surgery Authors: Source Type: blogs
Conclusion This study suggests that MRI could be an important tool in reducing the re-excision rates in the surgical management of HG DCIS. Although still controversial, selective MRI imaging can be useful in the preoperative diagnosis and evaluation of HG DCIS. Case by case discussion at MDT is crucial. Wider adaptation of MRI when indicated in the assessment of breast lesions with proper correlation to histology postoperatively is a key in improving our MRI interpretation skills, helping us to exploit the full scope of this useful tool.
Source: European Journal of Radiology - Category: Radiology Source Type: research
A 71-year-old man presented for dermatologic evaluation of multiple asymptomatic, 3- to 4-mm pink to translucent papules on the right lateral chest (Fig 1). Four years earlier, he had been diagnosed with stage IIIB invasive ductal carcinoma of the right breast and treated with mastectomy, axillary lymph node dissection, chemotherapy, and radiation. At the time of presentation, a computed tomography scan of his chest and a mammogram both failed to demonstrate breast cancer recurrence. A punch biopsy specimen of a papule was obtained, and the histopathologic evaluation revealed irregular, angulated vessels without complex an...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD Online Source Type: research
ConclusionIn this study, we provided UHR OCT images of different normal and malignant breast tissue types, and qualitatively and quantitatively studied the texture and optical features from OCT images of human breast tissue at different resolutions. We developed an automated approach to differentiate adipose tissue, fibrous stroma, and IDC within human breast tissues. Our work may open the door toward automatic intraoperative OCT evaluation of early‐stage breast cancer. Lasers Surg. Med. © 2017 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - Category: Laser Surgery Authors: Tags: Preclinical Report Source Type: research
Conclusions Dedicated breast PET may be a beneficial adjunct test following whole-body PET/CT in evaluating patients with breast cancer. Whole-body PET/CT offers advantages over dedicated breast PET, such as evaluation of systemic disease, lymph node involvement, and chest wall invasion. However, breast PET’s increased spatial resolution [reported as 1.6mm isotropic (1)] may aide in early detection of small lesions not visible on whole-body PET/CT, rendering these tools complimentary to each other for management of breast disease.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Technologist Posters Source Type: research
A 38-year-old woman presented with a mass in the left breast. Biopsy of the lesion revealed invasive ductal carcinoma. Bilateral adrenal metastasis was detected in whole body positron emission tomography scanning. Needle biopsy of the left adrenal lesion proved infiltration of malignant cells from breast carcinoma. After eight cycles of neoadjuvant (preoperative) chemotherapy, mastectomy, bilateral adrenalectomy, and bilateral oopherectomy were performed. No further hormonal treatment was recommended due to the resection of both adrenal glands and ovaries. The patient is still followed without any sign of progression. To o...
Source: Journal of Oncology Pharmacy Practice - Category: Cancer & Oncology Authors: Tags: Case Reports Source Type: research
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