Self-Scanned HIFU Ablation of Moving Tissue Using Real-Time Hybrid US-MR Imaging

Conclusion: The presented method does not require a learning stage and enables a duty cycle close to 100%, higher average acoustic intensity and avoidance of side lobe effects versus performing HIFU beam steering to compensate tissue motion. Significance: To our knowledge, the proposed method provides the first experimental validation of the self-scanning HIFU ablation paradigm via a real-time hybrid MRI/US imaging, opening the path toward self-scanning in vivo therapies.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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Conclusion: Our preliminary results indicate that 68Ga-PSMA-11-PET/MR has the potential to localize PCa recurrence after HIFU occult on mpMRI.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
CONCLUSIONS: Despite variation in size and location within the pelvis, ≥ 50 % of tumour volumes were considered targetable in 55 % patients while avoiding adjacent critical structures. A prospective treatment study will assess safety and symptom relief in a second patient cohort. ADVANCES IN KNOWLEDGE: Target size, location and access make MRgHIFU a viable treatment modality for treating symptomatic recurrent gynaecological tumours within the pelvis. PMID: 31084495 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conclusion: Our technique can model physiological respiratory motion more realistically and deals particularly well with the sliding of lungs against the rib cage. Significance: Our model-based sparse-to-dense image registration approach allows for accurate and realtime respiratory motion tracking in image-guided interventions.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Abstract For the successful completion of medical interventional procedures, several concepts, such as daily positioning compensation, dose accumulation or delineation propagation, rely on establishing a spatial coherence between planning images and images acquired at different time instants over the course of the therapy. To meet this need, image-based motion estimation and compensation relies on fast, automatic, accurate and precise registration algorithms. However, image registration quickly becomes a challenging and computationally intensive task, especially when multiple imaging modalities are involved. In th...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
CONCLUSIONS: The success rate was significantly higher for cyclodiode treatment as compared to HIFU cyclodestruction when treating refractory glaucoma. However, significantly fewer complications were observed with HIFU cyclocoagulation as compared to cyclodiode. PMID: 30139539 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
EDAP, based in Lyon, France, now has FDA clearance to bring to the U.S. its Focal One high intensity focused ultrasound system. It’s used to ablate prostate tissue in a non-invasive way, relying on sound waves to resonate tissue apart at the ce...
Source: Medgadget - Category: Medical Devices Authors: Tags: Radiology Urology Source Type: blogs
Authors: Huang SM, Liu HL, Li DW, Li ML Abstract High-intensity focused ultrasound (HIFU) has demonstrated the capacity to be used for local thermal ablation in clinical surgery; however, relying solely on conventional ultrasound B-mode imaging to monitor HIFU thermal ablation and determine ablation levels remains a challenge. Here, we experimentally demonstrate the ability to use Nakagami imaging to monitor HIFU-induced thermal lesions in porcine livers ex vivo. Ultrasonic Nakagami imaging has been proven to be able to characterize tissues with different scatterer concentrations and distributions. The pathological...
Source: Ultrasonic Imaging - Category: Radiology Tags: Ultrason Imaging Source Type: research
Conclusions: This are promising preliminary results, showing that 68Ga-PSMA-11-PET/MR might detect significant cancer after HIFU in patients with false negative mpMRI.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research
This article provides an overview of recent developments in diagnostic and therapeutic ultrasound, highlighting multiple innovation tracks and their translational potential.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Focus on Molecular Imaging Source Type: research
ConclusionsThe presence of an EBRT fiducial marker may result in an undertreated region beyond the marker due to reduced energy arriving at the focus, and an overtreated region in front of the marker due to reflections. Depending on the position of the targeted regions and the distribution of the markers, both effects may be undesirable and reduce treatment efficacy. Further work is necessary to investigate whether these results indicate the necessity to reconsider patient selection and treatment planning for prostate salvage HIFU after failed EBRT.
Source: Journal of Therapeutic Ultrasound - Category: Radiology Source Type: research
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