Metoclopramide for the treatment of diabetic gastroparesis.

Metoclopramide for the treatment of diabetic gastroparesis. Expert Rev Gastroenterol Hepatol. 2019 Jul 17;: Authors: Shakhatreh M, Jehangir A, Malik Z, Parkman HP Abstract Introduction: Gastroparesis is a chronic disorder of the stomach characterized by delayed gastric emptying without mechanical obstruction. Diabetes is the most commonly known cause of gastroparesis. Management of diabetic gastroparesis involves lifestyle modifications, glycemic control, pharmacological drugs, and for refractory cases surgical treatments. Metoclopramide remains the only drug approved by the Food and Drug Administration for diabetic gastroparesis. The aim of this article is to provide a concise review of the pharmacology, clinical efficacy and tolerability of metoclopramide. Areas Covered: We searched PubMed using the key words "metoclopramide", "diabetic gastroparesis", and "gastric emptying". The relevant articles and their bibliography were reviewed. Metoclopramide acts on several different receptors; primarily as a dopamine receptor antagonist, both peripherally improving gastric emptying, and centrally resulting in an anti-emetic effect. Metoclopramide side effects, mostly related to its ability to cross the blood-brain barrier, include drowsiness, restlessness, hyperprolactinemia, and tardive dyskinesia (TD), a movement disorder that may be irreversible. Expert Opinion: Metoclopramide carries a black box warning for use>12 weeks due ...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

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Publication date: Available online 20 June 2019Source: International Review of NeurobiologyAuthor(s): Xiaojiao Xu, Zhenfa Fu, Weidong LeAbstractParkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. Unfortunately, most of the currently used clinical therapies against PD are symptomatic and there is still no remedy can stop disease progression. Collective evidence shows that various kinds of exercise may reduce the risk of PD and do have positive impacts on both motor and nonmotor symptoms of PD. Additionally, exercise can also ameliorate the side effects such as wearing-off and dyskines...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Conclusions: Physical disorders among SMI patients vary by substance use disorder status. Clinicians managing SMI in patients should screen for physical disorders and substance use disorders and provide treatment or referral. Registration: International Prospective Register of Systematic Reviews (PROSPERO) registration number CRD42017072286. PMID: 31164045 [PubMed - as supplied by publisher]
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
As recently as 2017, there was still more talk than action in the clinical wearables market and the majority of companies making wearable devices were pursuing health and wellness applications first, with plans to pursue a medical device indication after the consumer version of the product took off. In some cases that is still true, but a panel of experts speaking at BIOMEDevice Boston 2019 highlighted a new trend. One that might seem unexpected for those who have been following the wearables market for the past five years or longer. "I'm in the medical space, I'm used to dealing with CGMs [continuous glucose monitors...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Software Source Type: news
In this study, we focused primarily on the change of sensory weighting parameters when sensory conditions change. We also tested the additional hypothesis that levodopa medication would improve sensory weighting for postural control. Materials and Methods Subjects The Institutional Review Board at Oregon Health and Science University (OHSU) approved the protocol for this experiment, and all subjects gave informed consent prior to participating. Eight subjects with PD (three female) and eight healthy, age-matched controls (two female) were recruited from the Balance Disorders Laboratory database and the Parkinson’s...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We report a man (current age: 59  years) without any underlying disease presenting with right‐hand tremor at the age of 39 years, followed by slow movement, rigidity, and postural instability. He developed motor fluctuation and levodopa‐induced dyskinesia 8 years later. At the age of 58 years, cognitive decline and visual h allucination ensued; he was institutionalized thereafter. We used multiplex ligation‐dependent probe amplification, which demonstrated no large deletions or duplications of relevant PD genes. Next, targeted sequencing panel covering 51 genes causative for PD was applied for the...
Source: Brain and Behavior - Category: Neurology Authors: Tags: REVIEW Source Type: research
Authors: Thiyagarajan M, Kamaraj E, Navrathan N, Thyagarajan M, Singh Krishna B Abstract Objectives: Pathogenesis of gallstone includes bile stasis due to defect in the gallbladder muscle contraction. Our aim of the study is to find out the role of 99mTc-HIDA scan in assessment of gallbladder dyskinesia in cholelithiasis patients before laparoscopic cholecystectomy and compare the gallbladder dyskinesia with various parameters like symptoms of patients, diabetic status of patients, gallstones size and number, and cholecystitis features in histopathology report after surgery. Material and Method: This is a prosp...
Source: Minimally Invasive Surgery - Category: Surgery Tags: Minim Invasive Surg Source Type: research
Authors: Shin SW, Lee JS, Abdi S, Lee SJ, Kim KH Abstract Going back to basics prior to mentioning the use of antipsychotics in patients with pain, the International Association for the Study of Pain (IASP) definition of pain can be summarized as an unpleasant experience, composed of sensory experience caused by actual tissue damage and/or emotional experience caused by potential tissue damage. Less used than antidepressants, antipsychotics have also been used for treating this unpleasant experience as adjuvant analgesics without sufficient evidence from research. Because recently developed atypical antipsychotics ...
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Publication date: March 2019Source: Biomedicine &Pharmacotherapy, Volume 111Author(s): Dongjian Chen, Chao Huang, Zhuo ChenAbstractLycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes, papayas, and watermelons. Previous studies have shown that lycopene can exert prophylactic and/or therapeutic effects in different disorders, such as heart failure and neoplasm via anti-oxidative, anti-inflammatory, and anti-proliferative activities. In the central nervous system (CNS), lycopene also has prophylactic and/or therapeutic effects in different type of disorders, such as Alzheimer’s diseas...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Abstract Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes, papayas, and watermelons. Previous studies have shown that lycopene can exert prophylactic and/or therapeutic effects in different disorders, such as heart failure and neoplasm via anti-oxidative, anti-inflammatory, and anti-proliferative activities. In the central nervous system (CNS), lycopene also has prophylactic and/or therapeutic effects in different type of disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), cerebral ischemia, epilepsy, and depression. Lycopene also imp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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