VetStem Biopharma Enters Pet Cancer Field with Key License from...

VetStem Biopharma has licensed a highly promising oncolytic virus cancer therapy platform from Calidi Biotherapeutics for use in veterinary medicine.(PRWeb July 18, 2019)Read the full story at
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news

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Publication date: 1 November 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 183Author(s): Jian-Tao Lin, Hua Chen, Dan Wang, Liang Xiong, Jia-Zhu Li, Gui-hong Chen, Guang-Bin ChenAbstractThe nucleus is one of the most important cellular organelles. Chitosan-grafted poly-(N-3-carbobenzyloxy-lysine) (CCL) decorated with human immunodeficiency virus-1 transactivator of transcription (TAT) can co-deliver p53 and doxorubicin into the nucleus simultaneously, such that their antitumor functions are exerted. However, TAT-CCL has been shown to have an anti-tumor effect only in vitro; the effect in vivo was unsatisfactory...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are commonly altered in cancers. As a receptor tyrosine kinase, EGFR’s kinase activity has been serving as the primary target for developing cancer therapeutics, namely the EGFR inhibitors including small molecules targeting its ATP binding pocket and monoclonal antibodies targeting its ligand binding domains. EGFR inhibitors have produced impressive therapeutic benefits to responsive types of cancers. However, acquired and innate resistances have precluded current anti-EGFR agents from offering sustainable benefits to initially responsi...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Conditions:   Cancer;   Cancer Cachexia;   Inflammation Interventions:   Other: Resistance Training;   Other: WB-EMS;   Other: High-intensity interval training (HIIT);   Other: Combined HIIT and Resistance Training (Combi) Sponsor:   University of Erlangen-Nürnberg Medical School Recruiting
Source: - Category: Research Source Type: clinical trials
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02118
Source: Analytical Chemistry - Category: Chemistry Authors: Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b00885
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - Category: Lipidology Source Type: research
Publication date: Available online 21 August 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Kyoung Tai NoAbstractX-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) target for cancer therapies. We used the fragment molecular orbital (FMO) method to study the binding modes and affinities between XIAP-BIR3 and a series of its inhibi...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
In this study, four novel ball-type Pc compounds were synthesized with 1,2-benzenediol as a substituent, including one non-metal complex (H4Pc2) and three metal-containing complexes (Mg2Pc2, Co2Pc2, and Zn2Pc2). The structures of the synthesized compounds were characterized using common spectroscopic methods. Quantum yields for fluorescence (ΦF), triplet state (ΦT), singlet oxygen (ΦΔ), and photodegradation (Φd) were measured except Co2Pc2 in dimethylsulfoxide. All the three compounds exhibited low fluorescence quantum yield, high triplet quantum yield, and good stability in organic solvent, suggestin...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Thorough understanding of growth and evolution of tissue vasculature is fundamental to many fields of medicine including cancer therapy, wound healing, and tissue engineering. Angiogenesis, the growth of new vessels from existing ones, is dynamically influenced by a variety of environmental factors, including mechanical and biophysical factors, chemotactic factors, proteolysis, and interaction with stromal cells. Yet, dynamic interactions between neovessels and their environment are difficult to study with traditional fixed time imaging techniques. Advancements in imaging technologies permit time-series and volumetric imag...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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