Cancers, Vol. 11, Pages 1006: Inhibition of DNA Repair Mechanisms and Induction of Apoptosis in Triple Negative Breast Cancer Cells Expressing the Human Herpesvirus 6 U94
In this study, we show the ability of U94 to exert its anticancer activity on three different TNBC cell lines by inhibiting DNA damage repair genes, cell cycle and eventually leading to cell death following activation of the intrinsic apoptotic pathway. Interestingly, we found that U94 acted synergistically with DNA-damaging drugs. Overall, we provide evidence that U94 is able to combat tumor cells with different mechanisms, thus attesting for the great potential of this molecule as a multi-target drug in cancer therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Francesca Caccuri Michele Sommariva Stefania Marsico Francesca Giordano Alberto Zani Arianna Giacomini Cornel Fraefel Andrea Balsari Arnaldo Caruso Tags: Article Source Type: research
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