Zinc oxide nanoparticles: Biosynthesis, characterization, antifungal and cytotoxic activity

Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Abdolhossien Miri, Nafiseh Mahdinejad, Omolbanin Ebrahimy, Mehrdad Khatami, Mina SaraniAbstractZinc oxide nanoparticles (ZnO-NPs) are multifunctional oxide metal nanoparticles that have been considered by many due to their unique properties including UV filtration, semiconducting, antimicrobial, antifungal, and photocatalytic activity. In the present study, ZnO-NPs have been synthesized from Zn(SO4)·7H2O through the use of “green synthesis” method that utilizes Prosopis farcta aqueous extract. The characterization of synthesized ZnO-NPs have been performed by UV–Vis absorption, Fourier-Transform Infrared spectroscopy (FT-IR), Raman, Powder X-ray Diffraction (PXRD), Transmission Electron Microscopy (TEM), Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-ray analysis (EDX). Results have illustrated that the synthesized nanoparticles contain a hexagonal shape and sheet form with sizes of 40–80 nm. The antifungal activity of ZnO-NPs against Candida albicans has shown that the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 128 and 256 μg/ml, respectively. The cytotoxicity activity of synthesized nanoparticles was tested on breast cancer cells (MCF7), while the IC50 was calculated to be 90 μg/ml.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research