Arterial and venous thrombosis by high platelet count and high hematocrit: 108,521 individuals from the Copenhagen General Population Study.

CONCLUSION: Multivariable adjusted hazard ratios for individuals with platelet counts in the top 5 percentiles (>398 x 109 /L) versus in the 25th -75th percentiles (231-316x 109 /L) were 1.77 (95% CI: 1.38-2.24) for arterial thrombosis in the brain (38 and 26 events/10,000 person-years) and 0.82 (0.61-1.11) for arterial thrombosis in the heart (23 and 28 events/10,000 person-years). For individuals with hematocrit values in the top 5 percentiles (women/men: > 45 / > 48%) versus the 25th -75th percentiles (women/men: 38.1-42 / 41.1-45%), hazard ratios were 1.27 (0.91-1.75) for arterial thrombosis in the brain (40 and 26 events/10,000 person-years) and 1.46 (1.06-2.00) for arterial thrombosis in the heart (43 and 25 events/10,000 person-years). Neither high platelet count nor high hematocrit was associated with risk of venous thromboembolism. When excluding individuals with myeloproliferative neoplasia from the main analyses, results on risk of thrombosis were similar. In this prospective study, high platelet counts were associated with 1.8-fold risk of arterial thrombosis in the brain while high hematocrit was associated with 1.5-fold risk of arterial thrombosis in the heart. This article is protected by copyright. All rights reserved. PMID: 31309714 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research