Guaiacum Toxicity: An Unusal Poisoning.
Guaiacum Toxicity: An Unusal Poisoning. J Assoc Physicians India. 2019 Apr;67(4):92 Authors: Bhushan D, Agarwal M Abstract Guaiacum is a homeopathic medicine used for arthritis, syphilis and tonsillitis. Its use as a substance abuse is not properly described in literature. Its excess intake may be life threatening and can damage the vision permanently. PMID: 31311227 [PubMed - in process]
ConclusionOverweight and obesity was higher in males as compared to females, those who were in the upper class and those who were older than 23 years.
The study explores thoughts, feelings, and beliefs of victims about their experiences of abuse and neglect and how therapeutic intervention encourages disclosure. Narrative accounts given by 15 Indian adolescents during therapeutic interventions were analy...
Conclusion: Our results show for the first time the relationship between serum levels of galectin and the clinical parameters of patients with RA. Demonstrating their role in pathogenesis, new studies with galectins are needed to assess how they function as a biomarker in RA. PMID: 31428469 [PubMed]
Authors: Abedi B, Reardon S, Winters KC, Lee S Abstract The present study used data from a randomized controlled trial on brief interventions with adolescents to identify distinct longitudinal patterns of substance use and identify predictors, as well as outcomes associated with those use patterns. Data were originally collected for the purpose of evaluating two brief intervention conditions with adolescents who had been identified in a school setting as abusing alcohol or other drugs (total sample, N = 315). Adolescents were randomly assigned to a two-session adolescent only brief intervention (BI-A), a two-sessio...
We describe the case of a 3-year-old Indian boy who presented with a 10-day history of pruritic pinpoint papules in multilinear bands on the left trunk. Three months before this presentation, he had similar lesions scattered on his trunk, without any specific distribution, that were consistent with lichen nitidus on histopathologic analysis, and self-resolved within a few days. Past birth, developmental, medical, and family history was unrevealing. The patient ’s family denied recent viral infections, new immunizations, or medication use.
Background: Apremilast is an oral phosphodiesterase 4 inhibitor approved for treatment of psoriasis and psoriatic arthritis (PsAs). The aim of this study was to evaluate the efficacy and safety of apremilast in a real-life cohort of patients with plaque psoriasis.
Background: Pityriasis versicolor (PV) is a superficial mycosis caused by malassezia yeast, which is a lipophilic fungus. Lesions may be of hypopigmented, hyperpigmented, or mixed varant. Low sensitivity and specificity of KOH examination poses a diagnostic challenge in difficult cases where dermoscopy can be a useful aid.
Introduction: Less than 10 cases of cutaneous panniculitides have been reported as adverse reactions to abatacept, with the most common reactions associated with oral contraceptives, nonsteroidal antiinflammatory drugs, antibiotics, and leukotriene-modifying agents. It is vital to recognize panniculitis drug reactions in rheumatologic patients for their future treatment options and the current understanding of cutaneous panniculitides associated with medications.
Background: The IL-17 receptor blocker brodalumab (BRO) was investigated in PsA in two double-blind, placebo (PBO)-controlled, phase III trials. Although terminated early by sponsor decision, sufficient patients were recruited to allow a meaningful evaluation of efficacy and safety.
Psoriasis is an inflammatory skin disease typically characterized by erythema, plaques and scaling. Proinflammatory cytokines including TNF- α, IL-23, and IL-17 are upregulated in psoriatic lesions and promote hyperproliferation of keratinocytes. Furthermore, psoriasis is seen as a systemic inflammatory disease associated with psoriatic arthritis, obesity and cardiometabolic comorbidities. Obesity negatively affects psoriasis disease se verity by producing proinflammatory adipokines by adipocytes and infiltrated immune cells and aggravates furthermore the cardiovascular risk in psoriasis patients.