Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation.

CONCLUSION: We provide the first evidence that key changes in Wnt signalling that drive murine anagen-induction also occur in human scalp HFs, yet with notable differences. This provides a rational basis for Wnt-targeting therapeutic interventions to manipulate human hair growth disorders. This article is protected by copyright. All rights reserved. PMID: 31314901 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Authors: Harrington P, Radia D, de Lavallade H Abstract INTRODUCTION: The outlook for patients with chronic myeloid leukaemia (CML) has changed dramatically with the development of tyrosine kinase inhibitors (TKIs) with the current treatment goal for many patients being to obtain a durable deep molecular remission, discontinue TKI therapy and remain treatment-free.Areas covered: In this article the authors review the data from the major TKI discontinuation studies, explore potential predictors of discontinuation outcome and look at possible mechanisms to explain the variable outcomes following TKI discontinuation i...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
ConclusionBM-MSCs delivered miR-222-3p via exosomes to inhibit cell proliferation and promote cell apoptosis by targeting IRF2 and negatively regulating IRF2/INPP4B signaling in THP-1 cells.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09362A, CommunicationYiqian Ren, Yao Qiang, Xinrui Duan, Zhengping Li In our report, we found a distinct difference in azido sugar metabolic rate between neural stem cells and fibroblasts, which can be used for selective removal of fibroblasts from neural... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Conclusion: It can be concluded that A/S similar to TGF ‑β1 is able to facilitate the chondrogenicdifferentiation of hADSCs and do not have adverse effects of TGF ‑β1. Thus, TGF‑β1 can be replacedby A/S in the field of tissue engineering.
Source: Dental Research Journal - Category: Dentistry Source Type: research
Contributors : Gurdeep Singh ; Scott Davidson ; Jennifer A MitchellSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe monitor the changes in genome-wide gene expression 6, 12 and 24 hours after removal of LIF and 2i from the ES cell culture media.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Jorge-Miguel F Martins ; Cornelius Fischer ; Alessia Urzi ; Ramon Vidal ; Severine Kunz ; Pierre-Louis Ruffault ; Loreen Kabuss ; Iris Hube ; Elisabetta Gazzero ; Carmen Birchmeier ; Simone Spuler ; Sascha Sauer ; Mina GoutiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cell Death &Disease, Published online: 20 January 2020; doi:10.1038/s41419-020-2233-6Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
d M. Al-Abd Thymoquinone (TQ) has shown substantial evidence for its anticancer effects. Using human breast cancer cells, we evaluated the chemomodulatory effect of TQ on paclitaxel (PTX). TQ showed weak cytotoxic properties against MCF-7 and T47D breast cancer cells with IC50 values of 64.93 ± 14 µM and 165 ± 2 µM, respectively. Combining TQ with PTX showed apparent antagonism, increasing the IC50 values of PTX from 0.2 ± 0.07 µM to 0.7 ± 0.01 µM and from 0.1 ± 0.01 µM to 0.15 ± 0.02 µM in MCF-...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ero The MYB binding protein 1A (MYBBP1A, also known as p160) acts as a co-repressor of multiple transcription factors involved in many physiological processes. Therefore, MYBBP1A acts as a tumor suppressor in multiple aspects related to cell physiology, most of them very relevant for tumorigenesis. We explored the different roles of MYBBP1A in different aspects of cancer, such as mitosis, cellular senescence, epigenetic regulation, cell cycle, metabolism plasticity and stemness. We especially reviewed the relationships between MYBBP1A, the inhibitory role it plays by binding and inactivating c-MYB and its regulation of...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusions: Overall, we propose that the four hub genes may be potential targets in trastuzumab-resistant gastric cancer and that ISGs may play a key role in promoting trastuzumab resistance in GC. PMID: 31949544 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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