Insights into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia from Engineered Human Heart Tissue.

CONCLUSIONS: Our study illuminates the molecular and cellular pathogenesis of CPVT and reveals a critical role of CaMKII-dependent reentry in the tissue-scale mechanism of this disease. We anticipate that this approach will be useful to model other inherited and acquired cardiac arrhythmias.
PMID: 31311300 [PubMed - as supplied by publisher]

Source: Circulation - July 16, 2019 Category: Cardiology Authors: Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK Tags: Circulation Source Type: research