IgA vasculitis as a presentation of human immunodeficiency virus infection

Publication date: Available online 17 July 2019Source: Reumatología Clínica (English Edition)Author(s): Anahy M. Brandy-García, Jorge Santos-Juanes, Silvia Suarez, Luis Caminal-MonteroAbstractIgA vasculitis is a small-vessel vasculitis mediated by immune complexes. In clinical terms, it is characterised by palpable purpura in the lower limbs, joint involvement in the form of arthralgia or arthritis, and gastrointestinal and renal involvement (this will mark a poorer prognosis in adults). Infectious processes, mainly in the upper respiratory tract, are frequently found to be triggers. On the other hand, human immunodeficiency virus (HIV) causes immune dysfunction, which triggers hypergammaglobulinemia and can trigger autoimmune disorders. At times, this can affect the vascular endothelium, giving rise to vasculitic manifestations, although there are few reports in the literature of its role in the presentation of HIV.ResumenLa vasculitis IgA es una vasculitis de pequeño vaso mediada por inmunocomplejos. Clínicamente se caracteriza por la púrpura palpable en miembros inferiores, la afectación articular en forma de artralgias o artritis y la afectación gastrointestinal y renal (esta última marcará el mal pronóstico en adultos). Es frecuente encontrar procesos infecciosos como desencadenantes, principalmente de vías respiratorias altas. Por otro lado, el VIH causa una disfunción inmunitaria que desencadena una hipergammaglobulinemia y puede desencadenar alteraciones ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research