Takayasu Arteritis: Recent Developments

AbstractPurpose of ReviewTakayasu arteritis (TA) is a granulomatous inflammatory disorder that affects large vessels, especially aorta and its proximal branches. Its diagnosis can be extremely challenging due to the non-specificity of the systemic inflammatory manifestations during the early phase of the disease and usually follows an insidious clinical course until the emergence of vascular ischemic complications.Recent FindingsIts pathogenesis has been better delineated in recent years, especially the role of HLA-B*52 allele in certain ethnic groups, as well as the use of biological therapy, and surgical revascularization. Recent findings are discussed in depth.SummaryClinical and epidemiological aspects of TA, recent developments in pathogenesis, and therapy are presented.
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research