Comparison between high-dose and low-dose intravenous methylprednisolone therapy in patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a common malignancy in the southern Chinese population [1]. Radiotherapy is the standard radical treatment for NPC and produces long-term effects. However, therapeutic irradiation increases the risk of neurologic injury, including radiation-induced brain necrosis (RN) [2], which is a common and serious complication among the many radiotherapy-related complications [3]. Furthermore, treatment of RN remains challenging. Treatment strategies such as anticoagulants [4], hyperbaric oxygen [5], and vitamins [6] have been reported in the past two decades, but their use is not widely accepted due to potential adverse effects and limited randomized control trials.

Source: Radiotherapy and Oncology - April 28, 2019 Category: Radiology Authors: Xiaohuang Zhuo, Xiaolong Huang, Maosheng Yan, Honghong Li, Yi Li, Xiaoming Rong, Jinpeng Lin, Jinhua Cai, Fukang Xie, Yongteng Xu, Keng Chen, Yamei Tang Tags: Original Article Source Type: research