Comparison between bone matching and marker matching for evaluation of intra- and inter-fractional changes in accumulated dose of carbon ion radiotherapy for hepatocellular carcinoma

Particle beams, especially carbon ion beams, are characterized by Bragg peak and a steep lateral penumbra that minimize damage to surrounding normal tissues while effectively concentrating damage on the tumor [1 –3]. However, because the sharper borders of the dose distribution are highly position-sensitive, the actual dose may differ from the prescribed dose if either the tumor position shifts or the water equivalent path length (WEL) to the tumor changes. Tumors of mobile organs such as the lung [4,5], liver [6], and pancreas may undergo greater changes [7], so their doses may be more affected by position shift.

Source: Radiotherapy and Oncology - May 7, 2019 Category: Radiology Authors: Yoshiki Kubota, Hiroyuki Katoh, Kei Shibuya, Shintaro Shiba, Satoshi Abe, Makoto Sakai, Daichi Yuasa, Kazuhisa Tsuda, Tatsuya Ohno, Takashi Nakano Tags: Original Article Source Type: research