Dimerization of the sodium/iodide symporter (NIS).

Conclusions We show for the first time that NIS dimerizes in vitro, and we identify the key residues via which this happens. We hypothesize that dimerization of NIS is critical to its trafficking to the PM, and may therefore represent a new mechanism which would need to be considered in overcoming therapeutic failure in patients with thyroid cancer. PMID: 31310151 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research