Amyotrophic lateral sclerosis type 8 is not a pure motor disease: evidence from a neuropsychological and behavioural study

ConclusionsALS8 patients present mild executive dysfunction and behavioural changes such as mood disorders, apathy and stereotypic behaviour. Our findings suggest that ALS8 is not a pure motor disorder and it is associated with subtle cognitive and behavioural impairments.
Source: Journal of Neurology - Category: Neurology Source Type: research

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In this study, we set out to investigate the percentage and absolute count of Tregs in major depressive disorder (MDD) patients and their correlation with disease severity. MATERIALS &METHODS: This is a case-control study consisting of 47 MDD patients and 47 healthy controls. MDD patients were treated with antidepressant drugs according to their physician's choice. The severity of MDD was assessed using Beck Depression Inventory (BDI) and Montgomery-Asberg Depression Rating Scale (MADRS) at the time of recruitment. Healthy controls completed the Depression Anxiety Scoring System (DASS21) questionnaire to ensure the...
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function, language and memory. However, the limited number of studies resulted in large confidence intervals. To obtain a more valid assessment, we updated the meta-analysis and included methodological improvements (controlled data extraction, risk of bias analysis and effect size calculation of individual neuropsychological tests). Embase, M...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Dementia, Motor neurone disease, Neuromuscular disease, Spinal cord, Memory disorders (psychiatry) Source Type: research
Conclusions: These preliminary results (we expect to present twice as many patients at the AAN congress) provide some evidence for longitudinal construct validity of the ALS-FTD-Q and show no progression of behavioral disturbances at 3-6 months follow-up. We recently added a behavioral interview with a proxy (gold standard) in order to investigate the longitudinal clinimetric properties of the ALS-FTD-Q.Disclosure: Dr. Govaarts has nothing to disclose. Dr. Beeldman has nothing to disclose. Dr. Beelen has nothing to disclose. Dr. Grupstra has nothing to disclose. Dr. Van Der Kooi has nothing to disclose. Dr. De Haan has not...
Source: Neurology - Category: Neurology Authors: Tags: Motor Neuron Disease: Clinical Trials, Treatment, and Outcome Source Type: research
Conclusion: OCs most frequently occur prior to the clinical diagnosis of FTD (in 78.3[percnt] of cases, 0 to 27 years before) and also co-occur with other psychiatric conditions like anxiety, depression and psychosis. Late-onset OCs can precede frank FTD, and thus merit further attention as an early marker of FTD.Disclosure: Dr. Santibanez has nothing to disclose. Dr. Sepehry has nothing to disclose. Dr. Feldman has received personal compensation for activities with Merck, Eli Lilly and Arena and Eisai and Genentech Banne as a member of safety and diagnostic monitoring committees. Dr. Hsiung has received research support f...
Source: Neurology - Category: Neurology Authors: Tags: Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Source Type: research
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