Transposons to V(D)J Recombination: Evolution of the RAG Reaction.

Transposons to V(D)J Recombination: Evolution of the RAG Reaction. Trends Immunol. 2019 Jul 13;: Authors: Lieber MR Abstract Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuclease deemed to be key in supporting this critical change in vertebrate advancement. PMID: 31307890 [PubMed - as supplied by publisher]
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Tags: Trends Immunol Source Type: research