Effects of Simultaneous Immunization of Haemophilus influenzae Type b Conjugate Vaccine and Diphtheria-Tetanus-Acellular Pertussis Vaccine on Anti-Tetanus Potencies in Mice, Guinea Pigs, and Rats.

In this study, we investigated the effect of HibT containing combination vaccines on anti-tetanus potencies by using animal models (mouse, guinea pig, and rat). HibT vaccine and HibT components of imported DTaP-HibT vaccine alone showed comparable or higher anti-tetanus potency than DTaP vaccine and DTaP-containing components of combination vaccines. Mixing these components before injection resulted in potencies greater than the sum of individual potencies. Injecting individual components at separate sites in animals resulted in potency roughly equivalent to the sum of the individual potencies. These results provide useful information regarding the use of HibT-containing multivalent vaccines in childhood immunization. PMID: 23429084 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/PubMed/23429084?dopt=Abstract

Source: Japanese Journal of Infectious Diseases - March 1, 2013 Category: Infectious Diseases Authors: Fukuda T, Iwaki M, Komiya T, Shibayama K, Takahashi M, Nakashima H Tags: Jpn J Infect Dis Source Type: research