Quantitative PCR is faster, more objective and more reliable than immunohistochemistry for the diagnosis of Cytomegalovirus Gastrointestinal disease in allogeneic stem cell transplantation

CMV infection and CMV disease after allogeneic stem cell transplantation (allo-SCT) are associated with significant morbidity. Since the introduction of pre-emptive anti-CMV therapy for CMV-seropositive recipients, the incidence of CMV disease during the first year after allo-SCT has decreased from approximately 35% to 8 –10% [1]. Well-known risk factors associated with CMV disease include CMV seropositivity, development of graft versus host disease (GvHD), prednisone treatment, and depletion of T cells from the graft.

Source: Biology of Blood and Marrow Transplantation - July 16, 2019 Category: Hematology Authors: Mar ía Suárez-Lledó, M.A. Ángeles Marcos, Miriam Cuatrecasas, Josep Antoni Bombi, Francesc Fernández-Avilés, Laura Magnano, Núria Martínez-Cibrián, Noemi Llobet, Laura Rosiñol, Gonzalo Gutiérrez-García, Sofía Jorge, Carmen Martínez, Montserr Source Type: research