Cancer Stem Cells in Solid Tumors.

Cancer Stem Cells in Solid Tumors. Curr Stem Cell Res Ther. 2019;14(5):374 Authors: Ortiz-Sánchez E Abstract PMID: 31309875 [PubMed - in process]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research

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Publication date: Available online 21 August 2019Source: Molecular Aspects of MedicineAuthor(s): Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-PanabièresAbstractMetastasis is the main cause of death in patients with cancer. The molecular mechanisms underlying the different metastasis steps are not yet fully known, partly because most studies have been focusing only on cancer cells within the tumor. Currently, with the development of technologies for the enrichment and capture of circulating tumor cells (CTCs), it is possible to characterize cancer cells at the exact moment of metastasis...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Conclusion Medication administration is an activity of great responsibility for nursing; however, in order to achieve a decrease in medication errors, prevention strategies are necessary for the whole health team. Implications for Practice Practice improvements are needed including establishing institutional drug administration protocols and keeping them updated, using a computerized prescription system, and promoting patient safety with staff.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Thorough understanding of growth and evolution of tissue vasculature is fundamental to many fields of medicine including cancer therapy, wound healing, and tissue engineering. Angiogenesis, the growth of new vessels from existing ones, is dynamically influenced by a variety of environmental factors, including mechanical and biophysical factors, chemotactic factors, proteolysis, and interaction with stromal cells. Yet, dynamic interactions between neovessels and their environment are difficult to study with traditional fixed time imaging techniques. Advancements in imaging technologies permit time-series and volumetric imag...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractImmunotherapy has led to a paradigm shift in the treatment of many advanced malignancies. Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and melanoma, checkpoint inhibition-based immunotherapy has limitations. Many tumors, such as pancreatic cancer, are less responsive to checkpoint inhibitors, where patients tend to have a limited duration of benefit and where clinical responses are more robust in patients who are positive for predictive biomarkers. One of the critical factors that influence the efficacy of immunotherapy is the tumor microenvironment (TME), which contains a hete...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
ichal Mego Lucia Kucerova Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We investigated the underlying mechanisms associated with cancer stem cell (CSC) markers and modalities circumventing the chemoresistance. Chemoresistant models (designated as CisR) of human embryonal carcinoma cell lines NTERA-2 and NCCIT were derived and characterized using flow cytometry, gene expression, functional and protein arrays. Tumorigenicity was determined on immunodeficient mouse model. Disulfiram was used to examine chemosensitization of resistant cells. ALDH1A3 isoform expression was evaluated...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Background: Outside the well-established role of the Sonic hedgehog (Shh) pathway in basal cell carcinoma(BCC) carcinogenesis, the transcriptional landscape of BCC remains incompletely understood. In particular, the contribution of ectopically expressed genes such as cancer testis(CT), embryonic stem cell(ESC) and meiomitosis genes is unknown. Using bioinformatics analyses on previously published BCC RNA-Sequencing(RNA-Seq) data, and experimental validation on our BCC samples, we searched for novel differentially expressed genes and pathways in BCC according to clinically relevant features.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 20 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Svetlana N. Aleksakhina, Aniruddh Kashyap, Evgeny N. ImyanitovAbstractSystemic therapy often results in the reduction of tumor size but rarely succeeds in eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT) and down-regulation of apoptosis are the most known general causes of therapy failure. Tumor escape from targeted compounds often involves pathway-specific mechanisms, which result in the restoration of the affected signaling ca...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 August 2019Source: Stem Cell ResearchAuthor(s): Flavia S. Donaires, Raquel M. Alves-Paiva, Fernanda Gutierrez-Rodrigues, Fernanda Borges da Silva, Maria Florencia Tellechea, Lilian Figueiredo Moreira, Barbara A. Santana, Fabiola Traina, Cynthia E. Dunbar, Thomas Winkler, Rodrigo T. CaladoAbstractTelomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short telomeres. X-linked dyskeratosis congenita (DC), the prototypical telomere disease, manifested with ectodermal dysplasia, cance...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Abstract The neural crest is a transient embryonic tissue that originates from the border of the neural plate prior to delamination and migration throughout the developing embryo, where it contributes to a wide range of different tissues. Defects in neural crest development have been implicated in a variety of different disorders (neurocristopathies) including cancers, neuropathies, craniofacial malformations, and pigment disorders. The differentiation of human pluripotent stem cells (hPSCs) into an in vitro counterpart to neural crest cells holds huge potential for the study of neural crest development, as well a...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
DiscussionThe observed resistance and functional integrity may form the basis for further investigations of MSCs as a potential therapy for antimetabolite-induced tissue damage.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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