The influence of pulmonary comorbidities on treatment choice and short-term surgical outcomes among elderly patients with colorectal cancer
AbstractPurposeMost elderly patients with colorectal cancer have comorbidities and reduced functional reserve, which may increase their risks of postoperative morbidity and mortality, and subsequently influence the treatment choice. Therefore, this study aimed to investigate the treatment choice and compare laparoscopic and open surgery in this setting.MethodsThis retrospective study evaluated 118 patients with colorectal cancer ( ≥ 85 years old between January 2007 and February 2018) to determine the influence of comorbidities on treatment choice, as well as the safety and feasibility of laparoscopic surgery for these patients.ResultsThe patients included 42 men (35.6%) and 106 patients (89.8%) with comorbidities. The treatments were curative resection for 90 patients and palliative surgery for 16 patients, including 5 cases of colostomy/ileostomy because of the difficulty of primary cancer resection, pneumonia, or pulmonary hypertension. Twelve patients received non-surgical treatment, including 7 patients with decreased respiratory function because of chronic obstructive pulmonary disease or pneumonia. Forty-three patients underwent open curative resection and 47 patients underwent laparoscopic curative resection, which was associated with a significantly shorter hospital stay (14 days vs. 19days,P
ConclusionElevated AURKB expression was strongly correlated to TMZ resistant acquisition and poor prognosis, furthermore, targeting AURKB would be a potential therapeutic target for GBM patients.
Purpose: To compare retinal thickness between patients with chronic hypertension without retinopathy, hypertensive retinopathy, Keith–Wagener–Barker Grade IV status, and normal controls using spectral domain optical coherence tomography. Methods: In this retrospective study, we analyzed patients who visited our retinal clinic from January 2013 to February 2016. Of those included, 58 eyes of 58 patients were in the healthy control group (Group A), 37 eyes of 37 patients were in the chronic hypertension without retinopathy group (disease duration of at least 10 years; Group B), and 31 eyes of 31 patients wit...
The objective of this article is to document whether DIRT can accurately map the position of the perforators and measure their influence on the perfusion of the flap in order to select the best perforators to improve the outcome of breast reconstructions with free DIEP flaps. A systematic review of the literature published between January 1998 and November 23th 2018 was conducted regarding the possible benefit of dynamic infrared thermography (DIRT) in DIEP-flap breast reconstructions.The databases PubMed and Web of Science were used to search for qualified articles. Inclusion criteria were women who underwent a breast rec...
Publication date: Available online 23 August 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Susie Brousse, Marine Joste, Franck Marie Leclère, Vincent Lavoué, Nicolas Bertheuil
ConclusionOur results support the hypothesis that the process of atherosclerotic plaque calcification presents a number of similarities with the physiological processes that occur in bone, involving both osteoblasts- and osteoclasts-like arterial cells. Finally, the present study suggests that risk factors, such as hypertension, cigarette smoke and diabetes, can cause the destabilization of the atheromatic plaque acting on calcification process as well as inflammation.
One woman's truly life-changing experience of caring for a mother with cancer.
Two studies explore outcomes for low-income, middle-aged adults.
No abstract available
Alpelisib (Piqray) is now approved to treat postmenopausal women or men who have hormone receptor–positive, human epidermal growth factor receptor 2–negative, PIK3CA-mutated, advanced or metastatic breast cancer that has progressed during or after endocrine-based therapy.
According to this study: Five years after gastric bypass, adolescents and adults had weight loss that was similar in magnitude.Remission of diabetes and hypertension occurred more often in adolescents than adults.