High frequency of hypoglycaemia in patients with type 1 diabetes mellitus attending a tertiary diabetes clinic in Durban, South Africa

The study aimed to assess the prevalence of hypoglycaemia in subjects with type 1 diabetes (T1D) attending a public health tertiary diabetes clinic in Durban, South Africa.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research

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ConclusionsThe above mention data demonstrated that the hematological profile showed noticeable alterations in children with T1DM and the inflammation and oxidative stress markers were contributed to the hematological abnormalities. The results revealed that some hematological indices can be used in the early detection of T1DM children at risk of diabetic complications.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In this study, there were significant differences between diastolic function parameters of the heart. The mitral isovolumic contraction time, contraction time, and isovolumic relaxation time values were different in the patients than in the controls (p
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Conclusion. These data demonstrate that DM may contribute to IDD by increasing aggrecan degradation and promoting cell apoptosis, which may represent early indicators of the involvement of DM in the pathogenesis of IDD. Level of Evidence: N/A
Source: Spine - Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research
Conclusion The usability test resulted in positive validation, and the suggestions contributed to improvement of the quality of the functions and interactions, favoring the achievement of the goals of the game. Thus, the technology has properties to improve the care of adolescents with type 1 diabetes mellitus.
Source: Acta Paulista de Enfermagem - Category: Nursing Source Type: research
Conclusion Educational actions on Facebook® are well accepted by young people and can be an important strategy to bring them closer to health services and help them in their self-care actions.
Source: Acta Paulista de Enfermagem - Category: Nursing Source Type: research
Long-acting basal insulins are used for the management of both type 1 and type 2 diabetes mellitus. Long-acting basal insulins were developed utilizing recombinant DNA technology and have been available since 2000 with the approval of insulin glargine U-100 followed by insulin detemir in 2005. In recent years, diabetes management has become more complex with the approval of insulin glargine U-300 and insulin degludec U-100 and U-200. Both insulin glargine U-300 and insulin degludec have been compared with insulin glargine U-100 and have demonstrated longer durations of action, as well as lower rates of hypoglycemia. This r...
Source: Cardiology in Review - Category: Cardiology Tags: New Therapy Source Type: research
In conclusion, chronic consumption of CO-HFD by T1DM-induced rats elicits significant biochemical and ultrastructural damage to rat atrial cells accompanied by elevated oxidative stress and mitochondria-mediated cell death. This article is protected by copyright. All rights reserved. PMID: 31398260 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
This article discusses the case of a child with type 1 diabetes who was successfully treated with a very low-carbohydrate diet, resulting in normal levels of HbA1c and normal blood glucose 95% of the time in a range of 70-180 mg/dL (4.0 mmol/L-10 mmol/L). Therefore, further studies are needed to verify how a very low carbohydrate diet impacts child development. PMID: 31393762 [PubMed - in process]
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
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