Euphonoids A−G, cytotoxic diterpenoids from Euphorbia fischeriana

Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Xue-Long Yan, Jun-Sheng Zhang, Jia-Luo Huang, Yao Zhang, Jia-Qi Chen, Gui-Hua Tang, Sheng YinAbstractSeven previously undescribed polycyclic diterpenoids, euphonoids A−G, including four ent-abietanes, two ent-atisanes, and one ent-kaurene, along with 26 known analogues were isolated from the roots of Euphorbia fischeriana. The structures of the undescribed compounds were elucidated by spectroscopic analysis, ECD calculations, and single crystal X-ray diffraction. Besides, the structure of a previously reported ent-abietane diterpenoid, fischeriabietane A, was revised. All the isolates were screened for the cytotoxicities against five cancer cell lines. Euphonoid A, fischeriabietane A, 11-oxo-ebracteolatanolide B, caudicifolin, jolkinolide B, and methyl-8,11-3-dihydroxy-12-oxo-ent-abietadi-13,15(17)-ene-16-oate showed significant inhibitory activities against human prostate cancer C4-2B and C4-2B/ENZR cell lines, with IC50 values being less than 10 μM. The brief structure-activity relationships (SARs) of these diterpenoids were also discussed.Graphical abstractSeven previously undescribed polycyclic diterpenoids along with 26 known analogues were isolated from the roots of Euphorbia fischeriana. Six compounds showed significant inhibitory activity against C4-2B and C4-2B/ENZR cell lines, with IC50 values being less than 10 μM.

Source: Phytochemistry - July 17, 2019 Category: Chemistry Source Type: research