Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by LXR Agonist.

Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by LXR Agonist. Antimicrob Agents Chemother. 2019 Jul 15;: Authors: Hwang J, Wang Y, Fikrig E Abstract The mosquito-borne Chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years, the virus has caused large epidemics in previously CHIKV-free geographic areas. To advance the understanding of host factors that antagonize CHIKV, we show that synthetic agonist of Liver X Receptor (LXR-623) inhibits CHIKV replication by upregulating the cholesterol exporter ABCA1, and that endogenous and pharmacological activation of interferon signaling pathway partners with LXR-623 to generate a superior antiviral state. PMID: 31307983 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research