Relation between DNA ionization potentials, single base substitutions and pathogenic variants

It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, d...

Source: BMC Genomics - July 16, 2019 Category: Genetics & Stem Cells Authors: Fabrizio Pucci and Marianne Rooman Tags: Research Source Type: research