Predictors of Mortality in Patients With Autoimmune Diseases Admitted to the Intensive Care Unit

Conditions:   Vasculitis;   Systemic Lupus Erythematosus;   Myositis Intervention:   Other: ICU Care Sponsors:   University of Göttingen;   University Medical Center Goettingen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We present a 53-year-old woman who presented simultaneously with acute inflammatory demyelinating polyneuropathy, Graves' disease, leukocytoclastic vasculitis, elevated acetylcholine antibody receptor antibodies and a mediastinal mass. Thymectomy was performed and revealed a type A thymoma and the clinical picture and paraclinical findings were consistent with a thymoma-associated multi-autoimmune syndrome (TAMA). Beside prednisolone and plasmapheresis, the patient was treated with tocilizumab and rituximab.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
We present a case of levamisole-induced vasculitis in the setting of chronic untreated systemic lupus erythematosus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
AbstractObjectiveTakayasu's arteritis (TAK) is a progressive autoimmune large vessel vasculitis with infiltration of pro ‐inflammatory T cells, while the etiology is largely unknown. Here we explore the involvement of mechanistic target of rapamycin (mTOR) in pro‐inflammatory T cell differentiation and disease progression of TAK patients.Methods95 patients with TAK, 26 patients with small vessel vasculitis and 40 healthy donors were enrolled. Na ïve and memory CD4+ T cells were activated with anti ‐CD3/CD28 beads and analyzed for lineage differentiations. mTORC1 activity was determined by quantifying intracellul...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification. J Autoimmun. 2019 Aug 17;:102316 Authors: Kapsogeorgou EK, Voulgarelis M, Tzioufas AG Abstract Sjögren's syndrome (SS) is a chronic systemic autoimmune disease, affecting predominantly the exocrine glands, a large array of systemic manifestations and high risk of lymphoma development. The latter constitutes the major adverse outcome of SS contributing in the increased morbidity and mortality of the disease. The vast majority of lymphomas in SS are B-cell non-Hodgkin's lymphomas (NHL),...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Conclusions: 1. Puts forward a hypothesis that infections can trigger autoimmunity in TAO development, in which TLR4, as a key role, can activate immune signaling pathways and induce autoimmune cytokines expression. 2. Suggests a reconsideration about the association between periodontal diseases and TAO, such as they just share the same high-risk population. Controlling periodontal disease severity in TAO studies may provide new clues. 3. For TAO treatment, endovascular intervention and autologous cell therapy both showed promising long-term therapeutic effectiveness, in which autologous cell therapy is becoming more popul...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Publication date: Available online 14 August 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): D. Gururaja, Veeraj HegdeAbstractSystemic Lupus erythematosus is the classic prototype of multisystem disease of autoimmune origin. SLE may be associated Vasculitis as an overlap syndrome. In this paper, a patient diagnosed as SLE with Vasculitis, which was managed successfully by Ayurveda treatment was discussed. A 39-year-old female patient came to hospital with complaint of severe pain and burning sensation in both the legs for two months, associated with ulceration and gangrene of toes of both the legs for th...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
We describe the immune correlates of reactivation of granulomatosis with polyangiitis (GPA)—an antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis—in a patient with metastatic urothelial carcinoma treated with pembrolizumab. After PD‐1 blockade, an inflammatory pulmonary nodule demonstrated a granulomatous, CD4+ T‐cell infiltrate, correlating with increased CD4+ and CD8+ naïve memory cells in the peripheral blood without changes in other immune checkpoint receptors. Placed within the context of the existing literature on GPA and disease control, our findings suggest a key role for PD‐1...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Precision Medicine Clinic: Molecular Tumor Board, Genitourinary Cancer Immune ‐ Related Adverse Events Source Type: research
Abstract Cryoglobulins are antibodies that precipitate at low temperatures and dissolve after rewarming. Cryoglobulinemia refers to the presence of circulating cryoglobulins and generally leads to a systemic inflammatory syndrome characterized by fatigue, arthralgia, purpura, ulcers, neuropathy and/or glomerulonephritis. The disease mainly involves small to medium-sized blood vessels and causes vasculitis due to cryoglobulin-containing immune complexes. Cryoglobulinemia is classified into three types (I, II and III) on the basis of immunoglobulin composition. Predisposing conditions include lymphoproliferative, au...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
CONCLUSIONS: These observations reveal interactions between restricted MPO epitopes and the adaptive immune system within ANCA vasculitis that may inform new antigen-specific therapies in autoimmune disease while providing insight into immunopathogenesis. PMID: 31383567 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
This article reports a case of coexistence of recurrent anti-GBM disease and T-cell large granular lymphocytic (T-LGL) leukemia. Patient concerns: A 37-year-old man presented with hematuria, edema, and acute kidney injury for 2 months. Diagnosis: Anti-GBM disease was diagnosed by renal biopsy, in which crescentic glomerulonephritis was observed with light microscopy, strong linear immunofluorescent staining for immunoglobulin G on the GBM and positive serum anti-GBM antibody. Given this diagnosis, the patient was treated with plasmapheresis, steroids, and cyclophosphamide for 4 months. The anti-GBM antibody titer was...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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