Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris.
Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris. Clin Cosmet Investig Dermatol. 2019;12:497-508 Authors: Farag AGA, Samaka R, Elshafey EN, Shehata WA, El Sherbiny EG, Hammam MA Abstract Background: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained. Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients. Methods: This case-control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation. Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P
AbstractTo systematically review the role of ultrasound (US) in the assessment of the joint-enthesial-nail apparatus in patients with psoriatic arthritis (PsA) or psoriasis (PSO) in terms of prevalence, diagnosis, prognosis, monitoring and treatment. A systematic literature review was conducted through medical databases (PubMed, Embase) and the grey literature up to February 2018. The main areas of application of nail US were first identified, allowing the development of research questions, which were rephrased following the PICOs methodology to develop inclusion criteria. Of the 585 studies produced by PubMed and Embase s...
In this report, we describe a case of a patient with a clinical history of systemic sarcoidosis and psoriasis who developed biopsy-confirmed perforating and necrotizing cutaneous granulomas after 12 months of treatment with adalimumab, a tumor necrosis factor-alpha–inhibiting, anti-inflammatory, biologic medication, prescribed for the patient's psoriasis. Although rare reports of a “sarcoidosis-like” reaction associated with select tumor necrosis factor-alpha agents exist, to the best of our knowledge, perforating and necrotizing cutaneous granulomas after treatment with adalimumab has not been previously...
Publication date: 5 October 2019Source: International Journal of Pharmaceutics, Volume 569Author(s): Mahdiyeh Bahramizadeh, Maryam Bahramizadeh, Bita Kiafar, Amir Hossein Jafarian, Amin Reza Nikpoor, Mahdi Hatamipour, Habibollah Esmaily, Zari Rezaeemehr, Shiva Golmohammadzadeh, Seyedeh Alia Moosavian, Mahmoud Reza JafariAbstractThe aim of this study was to prepare and characterize topical methotrexate (MTX) with different percentages (0.05%, 0.1%, 0.25% and 0.5%) entrapped in deformable liposomes using phosphatidylcholine and oleic acid. The effectiveness and sub-acute toxicity of these topical formulations were investigat...
Background: Scalp psoriasis is usually refractory to treatment. Excimer devices proved to be a promising therapeutic option in psoriasis. Greater efficacy of phototherapy can be achieved by a concurrent use of coal tar derivatives.
Introduction: Hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Introduction: Hidradenitis suppurativa (HS) and psoriasis has been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Background: The Auspitz sign, traditionally considered a characteristic feature of psoriasis, consists of pinpoint dotted bleeding, ensuing after scratching off the outer scales, due to the rupture of twisted, dilated, superficial capillaries. Modern noninvasive techniques that may enhance the diagnosis of psoriasis include videodermatoscopy (VD) and reflectance confocal microscopy (RCM). The aim of this study was to provide a comparison between VD, RCM, and horizontal histopathological sections of the psoriatic plaques showing the Auspitz sign.
Introduction: Patients with psoriasis have lowered QoL and are especially at risk of social stigmatization and discrimination. Only few studies have investigated the impact on the QoL of partners of psoriasis patients.
Background: To better understand the relationship between physician-reported measures of disease severity and patient-reported signs and symptoms of psoriasis, an analysis was conducted from clinical trials of brodalumab, a fully human anti –interleukin-17 receptor A monoclonal antibody approved for the treatment of moderate-to-severe plaque psoriasis.
This study further characterizes the associated impact of this PSP on outcomes among ADA-treated adults with psoriasis (PsO) in Europe.