Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris.

Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs. PMID: 31308720 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31308720?dopt=Abstract

Source: Clinical, Cosmetic and Investigational Dermatology - July 17, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research