An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids.

This study represents the first report of an unexpected new pathway for nitroxide radical production via hydrogen abstration reaction of a more reactive amidyl radical intermediate during the detoxification of the carcinogenic polyhalogenated quinones by N-alkyl hydroxamic acids, which provides more direct experimental evidence to better explain not only our previous finding that excess DFO can provide effective but only partial protection against TCHQ (or TCBQ)-induced biological damage, and also the potential side-toxic effects induced by DFO and other N-alkyl hydroxamic acid drugs. PMID: 31302229 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31302229?dopt=Abstract

Source: Free Radical Biology and Medicine - July 10, 2019 Category: Biology Authors: Xu D, Huang CH, Qin L, Xie LN, Mao L, Shao J, Kalyanaraman B, Zhu BZ Tags: Free Radic Biol Med Source Type: research