Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated / N-Tiophosphorylated Tacrine.

CONCLUSION: All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells (hepG2).
PMID: 31309898 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - July 15, 2019 Category: Chemistry Authors: Przybyłowska M, Inkielewicz-Stepniak I, Kowalski S, Dzierzbicka K, Demkowicz S, Daśko M Tags: Med Chem Source Type: research