Epithelial IDO1 Modulates AHR and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota

Inflammation, injury, and infection upregulate expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in the intestinal epithelium. We studied the effects of cell-specific IDO1 expression in the epithelium at baseline and during intestinal inflammation in mice.

Source: Gastroenterology - July 16, 2019 Category: Gastroenterology Authors: David M. Alvarado, Baosheng Chen, Micah Iticovici, Ameet I. Thaker, Nattalie Dai, Kelli L. VanDussen, Nurmohammad Shaikh, Chai K. Lim, Gilles J. Guillemin, Phillip I. Tarr, Matthew A. Ciorba Source Type: research