Challenges to drug discovery for celiac disease and approaches to overcome them

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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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AbstractCeliac disease (CD) is an immune-mediated enteropathy triggered by dietary ingestion of gluten in genetically susceptible patients. CD is often diagnosed by a “case-finding” approach of symptomatic patients. In recent times, the diagnostic paradigm has shifted to investigate patients who may be asymptomatic, but are at high risk of developing CD due to shared genetic susceptibilities. These high-risk groups include first-degree relatives of CD patient s and patients with Type 1 diabetes mellitus, autoimmune thyroid disease, Down’s syndrome, and Turner syndrome. Moreover, CD is often diagnosed as t...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
To the Editor: Celiac disease is an autoimmune disease resulting from an immune reaction to gluten that has a prevalence of 1% in the United States.1 Here, we present a unique case of celiac disease in a patient that initially presented with imaging findings of mesenteric fat stranding and hyperemia with prominent associated lymph nodes and small bowel hyperemia. .
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
ConclusionOur data suggest a role for CHI3L1 underlying the pathophysiology of CD and represent a starting point aiming to inspire new investigation that proves the possible use of CHI3L1 as a diagnostic factor and therapeutic target.
Source: Inflammation Research - Category: Research Source Type: research
In conclusion, DP-CAR for locally advanced pancreatic body/tail cancer can be performed safely with low mortality and provides survi val benefit when combined with neoadjuvant treatment.
Source: Updates in Surgery - Category: Surgery Source Type: research
Volume 24, Issue 2, April-June 2020, Page 126-134 .
Source: Journal of Consumer Health on the Internet - Category: Information Technology Authors: Source Type: research
Title: Inflammatory Bowel Disease, Celiac Are Linked: ReviewCategory: Health NewsCreated: 6/1/2020 12:00:00 AMLast Editorial Review: 6/2/2020 12:00:00 AM
Source: MedicineNet Digestion General - Category: Nutrition Source Type: news
This article describes the neurologic sequelae of various nutritional micronutrient deficiencies, celiac disease, inflammatory bowel disease, and liver disease. Where relevant, appropriate treatments for these conditions are also discussed. The developing field of the microbiome and nervous system interaction is also outlined. RECENT FINDINGS Pathology in the gastrointestinal system can affect the nervous system when it causes micronutrient deficiency, when immune responses created by the gastrointestinal system affect the nervous system, when toxins caused by gastrointestinal organ failure harm the nervous system, and ...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Source: Virchows Archiv - Category: Pathology Source Type: research
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Autoimmune diseases Source Type: blogs
Celiac disease (CD) is an immune mediated inflammatory enteropathy, triggered by gluten exposure in HLA-DQ2 and/or –DQ8 genetics. The presentation of celiac disease in children is changing, with increase in no...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
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