Dopaminergic Pathways in Obesity-Associated Inflammation

We present an explanatory hypothesis with a model that integrate central and peripheral dopaminergic circuits in the relationship between neuroimmune and metabolic systems in obesity-associated inflammation. A perspective on the potential role of dopaminergic drugs in the context of obesity will be given.Graphical AbstractGraphical representation of central and peripheral dopaminergic pathways in obesity-associated inflammation
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research

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This article is protected by copyright. All rights reserved. PMID: 31944292 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
Lifestyle keeps cardiovascular disease, cancer and type 2 diabetes at bay, research findsHealthy habits such as drinking in moderation, staying slim and exercising for at least 30 minutes a day could extend people ’s disease-free life by up to a decade, research suggests.Experts found that people who led a healthy lifestyle could expect to enjoy many more years of good health than those who smoked, drank too much or were overweight.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health World news Science Society Diabetes Fitness Cancer Life and style Source Type: news
In conclusion, all patients with DM should be undergo recommended age- and sex appropriate cancer screenings to promote primary prevention and early detection. Furthermore, cancer should be screened in routine diabetes assessment. PMID: 31902143 [PubMed - in process]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Authors: Wilson KM, Mucci LA Abstract A variety of diet and lifestyle factors have been studied with respect to prostate cancer risk in large, prospective cohort studies. In spite of this work, and in contrast to other common cancers, few modifiable risk factors have been firmly established as playing a role in prostate cancer. There are several possible explanations for the lack of well-established risk factors. First, prostate cancer has among the highest heritability of all common cancers; second, early life exposures may play an important role in risk, rather than mid- and later-life exposures assessed in most ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSION: Upregulation of LncRNAE330013P06 driven by type 2 diabetes is one of the factors which promoted progression of breast cancer. PMID: 31907990 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Lab Anal Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Metabolic syndrome (MetS) is a public health problem of great impact and significance. MetS is generally defined as a grouping of abdominal obesity, impaired glucose metabolism, dyslipidemia and hypertension and has an estimated national prevalence of approximately 34% [1,2]. The presence of MetS has been previously found to confer numerous adverse long-term health consequences, including an increased risk for cardiovascular disease, the development of type 2 diabetes mellitus, fatty liver disease and cancer [3 –6].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone...
Source: Journal of Nanobiotechnology - Category: Nanotechnology Authors: Tags: Review Source Type: research
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