Low Prevalence of the Four Common Colombian Founder Mutations in BRCA1 and BRCA2 in Early‐Onset and Familial Afro‐Colombian Patients with Breast Cancer

Conclusion.Our data showed a low prevalence of the BRCA1/2 founder mutations in Colombians of African descent, implying that these mutations should not be recommended for genetic screening programs in the Afro‐Colombian population.Implications for Practice.Risk reduction intervention programs are needed for women who are found to carry a BRCA1/2 mutation, as is the implementation of prevention programs for patients with inherited breast cancer, to reduce the burden of inherited diseases. With the aim of reducing racial disparities in breast cancer prevention, this study focused on genetic testing and treatment for patients in a minority population with BRCA1/2 mutations.

Source: The Oncologist - July 16, 2019 Category: Cancer & Oncology Authors: Elizabeth Vargas, Diana Maria Torres Lopez, Robert de Deugd, Fabian Gil, Aleȷandra Nova, Lina Mora, Luis Fernando Viana, Jose David Hernandez, Ricardo Bruges, Ute Hamann Tags: Breast Cancer, Global Health and Cancer Source Type: research