Osseous Tuberculosis - interdisciplinary treatment from diagnostics to microsurgical defect reconstruction - Case report and review of the literature and proposal of a therapeutic algorithm.

[Osseous Tuberculosis - interdisciplinary treatment from diagnostics to microsurgical defect reconstruction - Case report and review of the literature and proposal of a therapeutic algorithm]. Handchir Mikrochir Plast Chir. 2019 Jul 16;: Authors: Schloßhauer T, Priepke E, Rehart S, Kuehn S, Jahn-Muehl B, Rieger UM Abstract Tuberculosis is a central global health problem with an incidence of 10 million new cases per year and more than one million deaths per year. Contrary to this, osseous tuberculosis represents an extremely rare entity of tuberculosis. Osseous tuberculosis is challenging beginning with the correct diagnosis, adequate surgical as well infectiological treatment as well as extremity reconstruction. Facing increased migration and therefore increasing numbers of cases of tuberculosis in western countries, the question of a reliable diagnosis, therapy and protective measures in dealing with those patients is becoming increasingly important for Central Europe.In the present case, a 49-year-old female patient from Pakistan, the first presented to our institution with a clinical picture of an exanthema at the level of the upper ankle joint with radiological signs of osteolysis. Pathological and molecular pathological diagnostics revealed the presence of an infection caused by Mycobacteria tuberculosis complex. In the initial phase over 6 weeks, a 4-fold therapy with isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) and ethambutol (EMB) w...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research

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Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Conditions:   Mycobacterium Tuberculosis;   LTBI (Latent TB Infection);   Malnutrition;   Diabetes Mellitus;   Helminth Infections Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mycobacterium Tuberculosis;   LTBI (Latent TB Infection);   Malnutrition;   Diabetes Mellitus;   Helminth Infections Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mycobacterium Tuberculosis;   LTBI (Latent TB Infection);   Malnutrition;   Diabetes Mellitus;   Helminth Infections Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mycobacterium Tuberculosis;   LTBI (Latent TB Infection);   Malnutrition;   Diabetes Mellitus;   Helminth Infections Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   HIV Infections;   Tuberculosis Interventions:   Drug: Bictegravir (BIC);   Drug: Tenofovir alafenamide (TAF);   Drug: Cabotegravir (CAB);   Drug: Dolutegravir (DTG);   Drug: Atazanavir/ritonavir (ATV/r);   Drug: Darunavir/ritonavir (DRV/r);   Drug: Lopinavir/ritonavir (LPV/r);   Drug: Cobicistat;   Drug: Ritonavir;   Drug: First-Line TB Treatment;   Drug: Second-Line TB Treatment;   Drug: Doravirine (DOR) Sponsor...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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