Confirmation of thermal dose as a predictor of local control in cervical carcinoma patients treated with state-of-the-art radiation therapy and hyperthermia.
CONCLUSIONS: The positive association between thermal dose and clinical outcome is replicated in an independent, recent cohort of cervical carcinoma patients. Importantly, in patients receiving IGBT, the effect of thermal dose on clinical outcome is still observed. PMID: 31302345 [PubMed - as supplied by publisher]
Hepatocellular carcinoma (HCC) is the most common type of malignant primary liver tumour, accounting for 80 –90% of all liver cancers.  In the USA, for example, 30,640 new liver and intrahepatic bile duct cancers are estimated to have occurred in 2013, with 21,670 associated deaths. [2–3]
We present the case of a 51-year-old female patient with histopathologically confirmed diagnosis of a MANEC of the descending colon. At presentation, the tumor had already spread to the liver causing extensive hepatic metastases. Immunohistochemical examination showed 5%–10% of tumor cells to express the programmed cell death receptor ligand 1 and FoundationOne testing revealed a high mutational tumor burden with 149 Muts/Mb. The patient responded very well clinically and radiologically to anti-programmed death 1 receptor monoclonal antibody pembrolizumab therapy after having undergone 3 previous systemic treatment r...
ConclusionsDiscrepancies between planned activity and activity measured on90Y PET images were observed and seemed to be mainly related to clinical hazards and equipment issues. Predictive vs. post-treatment comparison of relative dose distributions between tumor and normal liver showed a good correlation and no significant difference highlighting the predictive value of99mTc MAA SPECT/CT-based dosimetry. Besides, the reproducibility of catheter tip position appears critical in the agreement between predictive and actual dose distribution.
ConclusionWhereas performed in patients with higher tumor burden, SIRT resulted in lower degrees of liver function worsening as assessed using MELD score variations.
Objectives: Lymphovascular space invasion (LVSI) is a known prognostic factor for endometrial carcinomas. However, LVSI as a determinant of treatment benefit has not been fully elucidated. Methods and Materials: Data from the National Cancer Database for endometrial cancer from 2004 to 2012 was obtained. Univariate and multivariate analysis was performed to assess the impact of LVSI on overall survival (OS). Survival analysis was performed utilizing log-rank and Kaplan-Meier analyses. The difference in OS between external beam radiation therapy (EBRT) and vaginal brachytherapy (VBT) in LVSI-positive patients was analy...
This study aimed to compare external radiation (beam radiation) and internal radiation as a single radiation therapy to advanced HCC patients (TNA stage III and IV according to the derived AJCC Stage, 6th edition) stratified by other risk factors, based on the data collected from the Surveillance, Epidemiology and End Results (SEER) national database. In this cohort study, we mainly clarified the following three points: 1. Choices of radiation therapy for advanced HCC patients vary in demographic and clinical factors. Among these, TNM classification is the key factor. 2. Internal radiation provides a better prognosis in bo...
Conclusion:Our results demonstrate, the overall survival of PC patients underwent SS was poor with nearly one third of patients dying within the first year and only one third surviving up to 3 years from the SS.Curr Urol 2018;12:142-146
Brachytherapy is an effective treatment for many keratinocyte carcinomas. However, the response to treatment is typically a clinical assessment and may be challenging to perform. The microscopic effect of ionizing radiation therapy on carcinoma as well as normal skin has never been well characterized. Reflectance confocal microscopy (RCM) is a novel in vivo skin imaging technique which may enable a better understanding of the response to brachytherapy at the histologic level. As part of an ongoing prospective clinical trial of electronic skin surface brachytherapy (ESSB), we performed RCM before and at specified times after treatment.
The first clinical trial in humans with skin and oral cavity squamous cell carcinoma (SCC) was performed in order to evaluate the effect of a unique intratumoral alpha radiation-based tumor ablation treatment termed Diffusing Alpha emitters Radiation Therapy (DaRT).
To investigate the survival impact of adding brachytherapy and or external beam radiation therapy to chemotherapy in patients diagnosed with stage IIIA uterine cancer.