Low-Frequency Fluctuations Amplitude Signals Exhibit Abnormalities of Intrinsic Brain Activities and Reflect Cognitive Impairment in Leukoaraiosis Patients.

CONCLUSIONS This research showed that LA patients exhibited abnormal intrinsic-brain activities. Furthermore, altered ALFF was positively correlated with executive function scores. PMID: 31302662 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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ConclusionThe MRAC research methods performed close to that of CTAC in the quantitative evaluation of [18F]FDG uptake and z-scores. Among the clinically implemented MRAC methods, DixonBone should be preferred for diagnostic assessment of dementia with [18F]FDG PET/MRI. However, as artifacts occur in DixonBone attenuation maps, they must be visually inspected to assure proper quantification.
Source: EJNMMI Research - Category: Radiology Source Type: research
Authors: Nishida H, Hayashi Y, Ban Y, Kudo T, Harada N, Sakurai T Abstract A 61-year-old dextral woman was admitted to the hospital with difficulty finding words. Neurological examinations confirmed that her speech was affected by frequent pauses and occasional phonological paraphasia without cognitive deficits. We detected atrophy, hypoperfusion, and hypometabolism in the right perisylvian and parietal regions, expanding to the right anterior temporal lobes and right inferior frontal gyrus (opercular region) by magnetic resonance imaging, single-photon emission computed tomography, and fluorodexyglucose-positron e...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
“I can’t say when we will have a cure, but we now know through our findings how to ask the question of what is going wrong at the earliest stage of Alzheimer’s. – John O’Keefe Alzheimer’s disease is a degenerative disease of the brain that affects more than 50 million people worldwide, and 5.8 million in America alone. Dementia is its most common form. According to the Alzheimer’s Association, someone in the United States develops Alzheimer’s every 65 seconds. While there’s currently no treatment or cure that can stop Alzheimer’s or slow progression of the disease...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Memory and Perception Alzheimer's disease Dementia Source Type: blogs
Rationale: Vascular cognitive impairment (VCI) is a common cause of dementia. Research suggests that hereditary factors (gene mutations) play an important role in the pathogenesis of VCI, and a mutation of the NOTCH3 locus is frequently identified in affected patients. Herein, we report the case of a patient with confirmed VCI associated with a NOTCH3 exon 33 gene mutation and review the relevant VCI literature. Patient concerns: A 48-year-old man presented to our neurology clinic with gradually progressive cognitive impairment. Diagnoses: Brain magnetic resonance imaging revealed multiple punctate hyperintensities...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, hyperactivation was found in individuals who later progressed to dementia, confirming that it might represent an early biomarker to identify individuals in the prodromal phase of AD and that its understanding could contribute to elucidate the key brain mechanisms that precede dementia.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 22 July 2019Source: NeuroImage: ClinicalAuthor(s): Leonie Beyer, Jonas Schnabel, Philipp Kazmierczak, Michael Ewers, Sonja Schönecker, Catharina Prix, Johanna Meyer-Wilmes, Marcus Unterrainer, Cihan Catak, Oliver Pogarell, Robert Perneczky, Nathalie L. Albert, Peter Bartenstein, Adrian Danek, Katharina Bürger, Johannes Levin, Axel Rominger, Matthias BrendelAbstractObjectivesMany predictive or influencing factors have emerged in investigations of the cognitive reserve model of patients with Alzheimer's disease (AD). For example, neuronal injury, which correlates with cognitive de...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
AbstractAs the worldwide population ages, the prevalence of Alzheimer's disease (AD) increases. However, the results of promising medications have been unsatisfactory. Chinese acupuncture has a long history of treating dementia, but lack of evidence from well-designed randomized controlled trials that validate its efficacy and safety, as well as its lack of clear underlying mechanisms, contribute to its limited application in clinical practice. In recent years, brain imaging technologies, such as functional magnetic resonance imaging and positron emission tomography, have been used to assess brain responses to acupuncture ...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
This study will be the first clinical trial to identify the therapeutic potential ofKami Guibi-tang for amnestic MCI. The findings will provide insight into the feasibility of large-scale trials to gather evidence for KGT as a treatment for MCI.Trial registrationKorean Clinical Trial Registry, ID:KCT0002407. Registered on 30 March 2017.
Source: Trials - Category: Research Source Type: clinical trials
Publication date: Available online 16 July 2019Source: NeuroImage: ClinicalAuthor(s): Alexa Haeger, Ana S. Costa, Jörg B. Schulz, Kathrin ReetzAbstractCurrent treatment in late-life cognitive impairment and dementia is still limited, and there is no cure for brain tissue degeneration or reversal of cognitive decline. Physical activity represents a promising non-pharmacological interventional approach in many diseases causing cognitive impairment, but its effect on brain integrity is still largely unknown. Especially research of cerebral alterations in disease state that goes beyond observations of clinical improvement...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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