Apelin-36 mitigates MPTP/MPP+-induced neurotoxicity: involvement of α-synuclein and endoplasmic reticulum stress.
Apelin-36 mitigates MPTP/MPP+-induced neurotoxicity: involvement of α-synuclein and endoplasmic reticulum stress. Brain Res. 2019 Jul 12;:146334 Authors: Zhu J, Dou S, Wang C, Jiang Y, Wang C, Cheng B Abstract Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons within the substantia nigra compacta (SNpc) which leads to the behavioral dysfunction. In the present study, we investigated the effect of Apelin-36 on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP)/1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity. The treatment with Apelin-36 significantly alleviated the MPTP-induced the behavioral dysfunction and dopaminergic neurodegeneration in the SNpc of mice, and also remarkably decreased the MPP+ -induced cell death of SH-SY5Y cells. Furthermore, Apelin-36 reversed the MPTP/MPP+ -induced loss of TH expression and the induction of α-synuclein expression. Additionally, Apelin-36 significantly attenuated the endoplasmic reticulum stress (ERS) indicated by the inhibition of GRP78, CHOP and cleaved caspase-12 expression in MPTP/MPP+ treated mice and cells. Taken together, the results indicated that Apelin-36 attenuates MPTP/MPP+-induced neurotoxicity, and suggested that Apelin-36 could be a potential therapeutic strategy for the treatment of PD. PMID: 31306618 [PubMed - as supplied by publisher]
In conclusion, our study further indicates that HIF1A plays a role in PD pathogenesis.
PARKINSON ’S disease is a long-term degenerative disorder of the central nervous system. One often overlooked symptom is hidden in a person’s nose. Do you have this nose symptom?
ConclusionThese results suggested that TGP can enhance dopaminergic neuron's cell survival in the SNpc in virtue of the activated cAMP/PKA/CREB factor of growth on inhibiting the pathway of second messenger apoptosis as well. In conclusion, the current findings indicate TGP is expected to be a new cure for PD.Graphical abstract
ConclusionsIncreased beat-to-beat HRV inLRRK2 G2019S mutation carriers compared with controls and idiopathic PD patients may indicate augmented cardiac autonomic cholinergic activity, suggesting early impairment of central vagal feedback loops in LRRK2-associated PD.
This study aimed to further investigate whether two different forms of Lf have neuroprotective effectsin vivo, and to examine their mechanisms, so as to provide an experimental basis for finding new therapeutic strategies against PD. In the central nervous system, Lf antagonized 1 ‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced DA depletion in the striatum, iron deposition, oxidative and apoptotic processes in the SN. Lf treatment down‐regulated iron import protein divalent metal transporter1 (DMT1) and up‐regulated iron export protein ferroportin1 (Fpn1), attenuating MPTP induced accumulation of...
CONCLUSIONS: Our results have not confirmed the presence of a presynaptic nigrostriatal deficit which could be related to asymmetry of DIP. The factors responsible for the asymmetry of DIP symptoms should be sought in the postsynaptic part of the nigrostriatal dopaminergic system. PMID: 31441498 [PubMed - as supplied by publisher]
CONCLUSIONS AND CLINICAL IMPLICATIONS: Postural deformities caused by dopamine agonists generally improve less than two weeks after dopamine agonist withdrawal. Given the response time in the present study, the response was unlikely to be caused solely by dopamine agonist withdrawal. Istradefylline can be a potential therapeutic option; however, appropriate selection of patients for treatment with istradefylline is warranted. PMID: 31441493 [PubMed - as supplied by publisher]
Abstract Neurodegenerative diseases are progressive and uncontrolled gradual loss of motor neurons function or death of neuron cells in the central nervous system (CNS) and the mechanisms underlying their progressive nature remain elusive. There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Currently, the development and identification of pluripotent stem cells enabling the acquisition of a large number of neural cells ...
This study aimed to describe the patterns of brain functional changes when VH occ ur in PD patients. Nine PD patients were enrolled because of their frequent and chronic VH (> 10/day). Patients with severe cognitive decline (MMSE
Gambling disorder is a pathologic condition, resulting from the interaction of multiple risk factors. Among these, dopamine neurotransmission is known for playing a significant role, as seen, for example, in patients using dopamine replacement therapy prescribed for Parkinson disease, in which gambling is considered to be iatrogenic. Considering this, together with the general mechanism of action of antipsychotic drugs, growing attention has recently been dedicated to Aripiprazole and to its partial dopaminergic agonism (reducing D2-receptor hyperactivation in the mesolimbic pathway and improving D2-receptor stimulation in...