Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity.

Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity. Swiss Med Wkly. 2019 Jul 01;149:w20104 Authors: Noutsios GT, Sharma S Abstract PURPOSE OF REVIEW: The aim of this review is to describe the co-occurrence of chronic rhinosinusitis (CRS) with other inflammatory illnesses of the lower respiratory system characterised by airway obstruction and hyperresponsiveness, such as asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD) in the context of the unified airway disease (UAD). We also sought to discuss the novel role of surfactant proteins as mediators of innate immunity in the sinonasal epithelium and their potential as therapeutic interventions. RECENT FINDINGS: Different epidemiological and physiological studies in CRS and asthma have outlined that there are common clustering patterns in the phenotypes/endotypes of both diseases, reinforcing the notion of the UAD. Also, surfactant proteins A (SP-A) and SP-D have now emerged as novel innate immunity molecules in bacterial sinusitis and allergic fungal sinusitis patients, respectively. SUMMARY: CRS and asthma coexist and are interconnected. Therefore, management of CRS and asthma must be jointly carried out as one functional entity. SP-A and SP-D bridge the innate and adaptive immunity mechanisms of the sinonasal epithelium to bring together a well-orchestrated mechanism that effectively fights pathogens. The use of ...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research

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ConclusionsThe benefits of FENO-based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: Food Quality and Preference - Category: Food Science Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 August 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Miao Zhou, Li Jiao, Yuanyuan LiuAbstractImbalance between inflammatory Th17 cells and immunosuppressive regulatory T cells (Treg) contributes to the progression of chronic obstructive pulmonary disease (COPD). We aims to investigate roles and mechanisms of secreted frizzled-related protein 2 (sFRP2) in airway inflammation and Th17/Treg differentiation in COPD. sFRP2 was significantly upregulated in the serum of patients with COPD and in human bronchial epithelial (HBE) cells that were exposed to cigarette smoke extra...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
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Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Authors: Tarazona-Meza CE, Nicholson A, Romero KM, Pollard SL, Gálvez-Davila RM, Hansel NN, Checkley W Abstract Rationale: Prior evidence suggests that there may be an association between asthma and food insecurity. We sought to describe the prevalence of food insecurity access, defined as having sufficient resources for appropriate foods in Lima, Peru, and evaluate its association with asthma status and control. Methods: We analyzed data from 553 children with asthma and 268 healthy controls aged nine to 19 years living in two peri-urban communities in Lima, Peru, in 2013. We used the Household Food ...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 16 August 2019Source: The Lancet Respiratory MedicineAuthor(s): Brian O'Sullivan
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Health Sensors & Trackers Portable Diagnostics blood bodily fluid digital digital health digital solutions digital tattoo saliva smart smart healthcare sweat technology urine Source Type: blogs
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