Designing Developmentally Sensitive AAC Technologies for Young Children with Complex Communication Needs: Considerations of Communication, Working Memory, Attention, Motor Skills, and Sensory-Perception
This article provides an overview of specific, early developmental milestones in communication, cognition (i.e., attention and working memory), motor skills, and sensory-perception (including visual attention) that influence decisions regarding AAC system design for young children. Developmental considerations are also reviewed for young children with Down's syndrome, a group that often benefits from early provision of AAC. Based on developmental theory and milestones, specific recommendations are provided for the design of developmentally sensitive AAC technologies for young children who are beginning communicators. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text
Authors: Wong OGW, Ngan HYS, Cheung ANY PMID: 31416985 [PubMed - in process]
Condition: Down Syndrome Intervention: Behavioral: Speech therapy addressing phonology and motor learning Sponsors: University of Wisconsin, Madison; Office of the Vice Chancellor for Research and Graduate Education; Wisconsin Alumni Research Foundation Not yet recruiting
Genetics in Medicine, Published online: 16 August 2019; doi:10.1038/s41436-019-0637-4Detection of iron deficiency in children with Down syndrome
Publication date: August 2019Source: Alzheimer's &Dementia, Volume 15, Issue 8Author(s): Ranjeet Singh Mahla
Introduction Individuals with intellectual disabilities (ID) are often sedentary and have low fitness levels. Current knowledge supports the existence of physiological barriers resulting in low fitness and exercise intolerance in individuals with Down syndrome, which might be applicable to other ID etiologies. If physiological barriers exist in ID, this would require adaptation of the physical activity guidelines. Purpose The aim of this study was to assess differences in cardiopulmonary profiles, including maximal oxygen uptake, during a cardiopulmonary exercise test in individuals with ID without Down syndrome and h...
Publication date: Available online 13 August 2019Source: Meta GeneAuthor(s): Pinku Halder, Upamanyu Pal, Anirban Ray, Sumantra Sarkar, Supratim Dutta, Sujay GhoshAbstractWe have tested maternal polymorphic variants MTR A2756G (rs1805087), MTRR A66G (rs1801394), MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) for their association with meiotic errors in oocyte and Down syndrome birth among 730 controls and 1019 case mothers having Down syndrome child from Bengali speaking population of India. We demonstrated significant association of MTR A2756G (rs1805087), MTRR A66G (rs1801394), MTHFR A1298C (rs1801131), but not MTHF...
Publication date: 12 August 2019Source: Cancer Cell, Volume 36, Issue 2Author(s): Yehudit Birger, Ruth Shiloh, Shai IzraeliStudies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.
Authors: Ji D, Hu G, Zhang X, Yu T, Yang J Abstract Aberrant expression of long non-coding RNA DSCAM-AS1 (Down Syndrome Cell Adhesion Molecule antisense) has been observed in several cancers. However, the expression status, biological function and underling mechanism of DSCAM-AS1 in hepatocellular carcinoma (HCC) remain unclear. The expression of DSCAM-AS1 was detected in HCC tissues and serum from both HCC patients and healthy controls. MTS, wound healing and transwell invasion assays were used to examine the effects of DSCAM-AS1 on cell proliferation, migration, and invasion in HCC cells, respectively. MicroRNAs ...
CONCLUSION: The prevalence of live birth with DS is high in the low socioeconomic group and the healthcare costs for the children with DS are significantly higher than those for non-DS children. Therefore, health authorities should help mothers at lower socioeconomic levels to receive adequate antenatal care and consider the cost of medical care for children with DS. PMID: 31392854 [PubMed - in process]
Conclusions Small changes to the organization of the simulated augmentative and alternative communication display resulted in substantial differences in eye gaze and speed to find a target. Of greatest clinical import is the finding that clustering symbols reduced attention to distracters, given that individuals with disabilities may be prone to distraction. PMID: 31398294 [PubMed - as supplied by publisher]