Parkinson ’s disease study identifies possible new treatment target

A new study by Yale researchers challenges long-held assumptions about dopamine ’s role in Parkinson’s treatment.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Condition:   Parkinson's Hallucinations Intervention:   Drug: Ondansetron 8mg or matched placebo Sponsors:   University College, London;   MODEPHARMA Limited;   PARKINSONS UK;   PRIMENT;   SEALED ENVELOPE;   Wasdell Packaging Ltd;   Custom Pharmaceuticals Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson's Disease Intervention:   Biological: AAV2-GDNF Sponsor:   Brain Neurotherapy Bio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: As it is detected by a survey performed by telephone calls with good interrater reliability, patients with PD gets better with LCIG treatment in many aspects of the disease. PMID: 31731332 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Publication date: Available online 18 November 2019Source: The Lancet NeurologyAuthor(s): John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson, Timothy G DinanSummaryResearch into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Abstract About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer's and Parkinson's diseases. Although direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps an a...
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
Publication date: Available online 18 November 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Yu-hua ZHAOAbstractIn this article, one proved case of flaccid tongue treated by Guan's tongue acupuncture was introduced by the three-step method of “puncture, prick, and swallowing”. This case was an elderly female patient with Parkinson disease, which had the main clinical symptoms of flaccid and weak tongue, and speech and swallowing disorder, and was diagnosed as flaccid tongue (deficiency of the both qi and blood, and deficiency syndrome of liver and kidney). The patient received diagnosis and t...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Contributors : Tim Ahfeldt ; Lee RubinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose of NGS transcriptomics: We generated RNA-sequencing transcriptomics datasets from isogenic Parkinson ’s disease (PD) HUES1 cell lines (harboring loss of function mutations in either PARKIN (PRKN), DJ-1-/- (PARK7), or ATP13A2-/- (PARK9)) to identify common and distinct dysregulated genes and networks in our three isogenic PD lines in an unbiased way, with the goal of grouping similar and distinct forms of PD and identify common or divergent dysregulation.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Depression and anxiety are common neuropsychiatric manifestations of Parkinson disease. However, they are often under-recognized because the somatic symptoms of depression often overlap with the motor symptoms of Parkinson disease and there is low self-rep...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 18 November 2019Source: NeuroImage: ClinicalAuthor(s): Yi-Ai Rau, Shi-Ming Wang, Jacques-Donald Tournier, Sung-Han Lin, Chin-Song Lu, Yi-Hsin Weng, Yao-Liang Chen, Shu-Hang Ng, Shao-Wen Yu, Yi-Ming Wu, Chih-Chien Tsai, Jiun-Jie WangAbstractIntroduction: Disruption to white matter pathways is an important contributor to the pathogenesis of Parkinson's disease. Fixel-based analysis has recently emerged as a useful fiber-specific tool for examining white matter structure. In this longitudinal study, we used Fixel-based analysis to investigate white matter changes occurring over time in patie...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Discussion: Our results suggest that a tele-health-based approach is both feasible and efficient in providing rehabilitation care to CNDs from clinic to home. Increasing and maintaining participation as well as autonomy in daily routine are promising findings that open up scenarios for the continuity of care at home through DH-care for CNDs.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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