Cytokines (IL-15, IL-21, and IFN- γ) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity

ConclusionsOur results suggest that the increased soluble levels of IL-15, IL-21, and IFN- γ are involved in the inflammatory network in RA. However, IL-21 serum levels are associated with higher titers of autoantibodies (RF, anti-CCP, and anti-MCV) and IL-15 with moderate activity.Key Points• IL-15, IL-21, and IFN-y are associated with the immunopathology of RA, but not significantly with the evolution of the disease.• RF, anti-CCP, and anti-MCV had higher levels in early than established RA.• IL-21 has an association with RF, anti-CCP, and anti-MCVand, for this reason, could be proposed as a disease biomarker.• Patients with activity moderate of disease showed higher levels of RF, anti-CCP, anti-MCV, and IL-15.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research