Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls

Precursors of pancreatic cancer arise in the ductal epithelium; markers exfoliated into pancreatic juice might be used to detect high-grade dysplasia (HGD) and cancer. Specific methylated DNA sequences in pancreatic tissue have been associated with adenocarcinoma. We analyzed these methylated DNA markers (MDMs) in pancreatic juice samples from patients with pancreatic ductal adenocarcinomas (PDACs) or intraductal papillary mucinous neoplasms (IPMNs) with HGD (cases), and assessed their ability to discriminate these patients from individuals without dysplasia or with IPMNs with low-grade dysplasia (IPMN-LGD) (controls).

Source: Clinical Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: Shounak Majumder, Massimo Raimondo, William R. Taylor, Tracy C. Yab, Calise K. Berger, Brian A. Dukek, Xiaoming Cao, Patrick H. Foote, Chung Wah Wu, Mary E. Devens, Douglas W. Mahoney, Thomas C. Smyrk, Rahul Pannala, Suresh T. Chari, Santhi Swaroop Vege, Source Type: research