Durability of Spontaneous and Treatment-related Loss of Hepatitis B s Antigen
Clearance of hepatitis B surface antigen (HBsAg) from serum is the most desirable endpoint and a proposed definition of functional cure for hepatitis B virus (HBV) infection. However, little is known about the long-term durability of HBsAg loss, and there is controversy over whether the development of antibodies against HBsAg (anti-HBs) is required for maintenance. We aimed to assess the durability of spontaneous or treatment-related (interferon or nucleos(t)ide analogue [NA]) loss of HBsAg.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Ahmad Samer Alawad, Sungyoung Auh, Daniel Suarez, Marc G. Ghany Source Type: research