Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann –Pick C1 Disease

ConclusionsThe low and static levels of intestinal UC sequestration inNpc1−/− mice likely reflect the continual sloughing of cells from the mucosa. This sequestration is blunted by about the same extent following a single acute treatment with 2HP βCD as it is by a prolonged ezetimibe-induced block of cholesterol absorption.

Source: Digestive Diseases and Sciences - July 16, 2019 Category: Gastroenterology Source Type: research