Five 'mental disorders' may have genetic links

Conclusion This study suggests that autism, ADHD, clinical depression, bipolar disorder and schizophrenia may have common genetic risk factors. The five conditions examined in this study were selected on the basis of the availability of a large genetic data set. It is unclear at this stage whether other relatively common mental health conditions (such as anxiety disorder or obsessive compulsive disorder) are also affected by these genetic variations, or whether there is overlap with other conditions. Perhaps most importantly, these variations cannot on their own predict or explain the development of autism, ADHD, depression, bipolar disorder or schizophrenia. The researchers point out that – as with almost all genome-wide association studies of complex conditions – the effect of the individual variations identified in these four regions was small, and cannot predict or diagnose these mental health conditions. However, the researchers report that evidence from a variety of research, "including that from clinical, epidemiological and molecular genetic studies, suggests that some genetic risk factors are shared between neuropsychiatric disorders." They suggest that this study adds to such evidence, and provides "insights into the shared causation of psychiatric disorders". These insights are, specifically, that changes in calcium signalling could be a fundamental biological mechanism "contributing to a broad vulnerability to psychopathology...
Source: NHS News Feed - Category: Consumer Health News Tags: Genetics/stem cells Mental health Source Type: news

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CONCLUSION: Our results suggest that the use of a BCI after SA does not lead to increased consumption of medical care. PMID: 30551792 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Publication date: Available online 15 December 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Lan Zhou, Shupei Tang, Lu Yang, Xiaoyong Huang, Ling Zou, Yu Huang, Shiwu Dong, Xinyuan Zhou, Xiaochao YangAbstractCerium and cerium containing materials have been drawing increasing attentions in industrial and biomedical applications in recent decades. The increased applications of cerium have also increased the risk of human body exposed to cerium ions. Due to its similar ionic radius to calcium(II), cerium(III) have found mainly deposited in the skeletal system. However, the effects of cerium(III) on t...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: 1 February 2019Source: Journal of Non-Crystalline Solids, Volume 505Author(s): Alesh Kumar, C.R. Mariappan, B.S. SarahanAbstractStructural, electrical, bioactivity and antibacterial properties of mesoporous Ag doped calcium borosilicate glass-ceramics are reported. A simple sol-gel route was used to synthesize the mesoporous glass-ceramics. N2 adsorption–desorption studies reveal the mesoporous structure of the samples. The embedment of nano-sized Ag metallic particles in glass matrix was confirmed for Ag doped sample calcined at 600 °C by X-ray diffraction, UV–visible, and transmission ...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
ConclusionThe problem of the radon exposure is still unresolved and needs further studies on bigger human cohorts in order to search for more sensitive biomarkers.
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Authors: Brignardello-Petersen R PMID: 30551798 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
This study suggests that long-term occupational exposure to ELF-EMF may lead to depression, stress, anxiety and poor sleep quality. PMID: 30547710 [PubMed - as supplied by publisher]
Source: Electromagnetic Biology and Medicine - Category: Physics Tags: Electromagn Biol Med Source Type: research
Publication date: Available online 15 December 2018Source: The Lancet NeurologyAuthor(s): Ralf Reilmann, Andrew McGarry, Igor D Grachev, Juha-Matti Savola, Beth Borowsky, Eli Eyal, Nicholas Gross, Douglas Langbehn, Robin Schubert, Anna Teige Wickenberg, Spyros Papapetropoulos, Michael Hayden, Ferdinando Squitieri, Karl Kieburtz, G Bernhard Landwehrmeyer, European Huntington's Disease Network, Pinky Agarwal, Karen E Anderson, Nasir A Aziz, Jean-Phillippe Azulay, Anne C Bachoud-LeviSummaryBackgroundPrevious trials have shown that pridopidine might reduce motor impairment in patients with Huntington's disease. The aim of this...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Authors: Nurnberger JI, Austin J, Berrettini WH, Besterman AD, DeLisi LE, Grice DE, Kennedy JL, Moreno-De-Luca D, Potash JB, Ross DA, Schulze TG, Zai G Abstract The International Society of Psychiatric Genetics (ISPG) created a Residency Education Committee with the purpose of identifying key genetic knowledge that should be taught in psychiatric training programs. Thirteen committee members were appointed by the ISPG Board of Directors, based on varied training, expertise, gender, and national origin. The Committee has met quarterly for the past 2 years, with periodic reports to the Board and to the members of the...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: Among younger persons, HD was associated with lower rates of efficacy failure than PP. Age effects on adverse effects were mixed. Age-related heterogeneity of antipsychotic treatment effects warrants further investigation and consideration in clinical practice. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01136772. PMID: 30549494 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Authors: Komrad MS, Pies RW, Hanson AL, Geppert CMA PMID: 30549491 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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