Five 'mental disorders' may have genetic links

Conclusion This study suggests that autism, ADHD, clinical depression, bipolar disorder and schizophrenia may have common genetic risk factors. The five conditions examined in this study were selected on the basis of the availability of a large genetic data set. It is unclear at this stage whether other relatively common mental health conditions (such as anxiety disorder or obsessive compulsive disorder) are also affected by these genetic variations, or whether there is overlap with other conditions. Perhaps most importantly, these variations cannot on their own predict or explain the development of autism, ADHD, depression, bipolar disorder or schizophrenia. The researchers point out that – as with almost all genome-wide association studies of complex conditions – the effect of the individual variations identified in these four regions was small, and cannot predict or diagnose these mental health conditions. However, the researchers report that evidence from a variety of research, "including that from clinical, epidemiological and molecular genetic studies, suggests that some genetic risk factors are shared between neuropsychiatric disorders." They suggest that this study adds to such evidence, and provides "insights into the shared causation of psychiatric disorders". These insights are, specifically, that changes in calcium signalling could be a fundamental biological mechanism "contributing to a broad vulnerability to psychopathology...
Source: NHS News Feed - Category: Consumer Health News Tags: Genetics/stem cells Mental health Source Type: news

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ConclusionsOur results confirm the dimensional distribution of autistic traits and related symptoms in unselected populations across different cultures. The Q−CHAT is a valid and reliable dimensional screening instrument to be used within a routine paediatric setting during well-child assessments.The main normative data and factor structure replicated in our sample
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Authors: Cui T, Li Z, Zhou Q, Li W Abstract Diploidy is the typical genomic mode in all mammals. Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells, which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale. To date, a multitude of haploid stem cell types from mouse, rat, monkey and humans have been derived, as more are in development. They have been applied in high-throughput genetic screens and mammalian assisted reproduction. Here, we review t...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Contributors : Jared A Sewell ; Jeff A LongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaGene regulation in both plants and animals is orchestrated by complex interactions between multiple, often times related, factors. How these related factors interact and compete to alter gene expression is a key question that is not fully understood. In Arabidopsis, the Class III Homedomain-Leucine Zipper (HD-ZIPIII) family of transcription factors regulates key developmental processes such as shoot stem cell formation and display complex genetic interactions. We show that ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
Contributors : Jared A Sewell ; Jeff A LongSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaGene regulation in both plants and animals is orchestrated by complex interactions between multiple, often times related, factors. How these related factors interact and compete to alter gene expression is a key question that is not fully understood. In Arabidopsis, the Class III Homedomain-Leucine Zipper (HD-ZIPIII) family of transcription factors regulates key developmental processes such as shoot stem cell formation and display complex genetic interactions. We show that HD-ZIPIIIs for...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
Contributors : K S Rakesh ; Dawood B Dudekula ; Ramaiah Nagaraja ; Minoru S Ko ; Yulan Piao ; David Schlessinger ; Ramamoorthy Kalidoss ; Ravi SirdeshmukhSeries Type : Expression profiling by arrayOrganism : Mus musculusWe have studied protein expression in mouse embryonic stem (mES) cells- R1-9 and identified the largest complement of proteins reported thus far for mES cells, using on-line LC-MS/MS analysis. With support from a transcriptome profile of the same mES cell line, we arrived at an integrated dataset of 9,370 protein expressions that may be useful to understand the stem cell dynamics. 6,278 protein identificati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 20 April 2019Source: PhytochemistryAuthor(s): Devashan Naidoo, Martin Pošta, Ayan Roy, Manoj Kulkarni, Johannes Van StadenAbstractSmoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR1 displayed the most encouraging activity returning IC50 values of 13.75 ± 0.001 μM and 0.03 ± 0.02 μM for monoamine oxidase A and B and 0.08 ± 0.006 μM for acetylcholinester...
Source: Phytochemistry - Category: Chemistry Source Type: research
Publication date: Available online 20 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Enrico Riccardi, Thomas TichelkampAbstractThe influence of ion type at constant ionic strength on the surfactant layer present between a polar and a non-polar liquid has been investigated. The investigated systems are composed of sodium bis(2-ethylhexyl) sulfosuccinate (AOT), dodecane and brines with different electrolyte compositions. Parallel and coordinated sampling have been performed via molecular dynamics simulation and experiments. By varying the molar ratio between calcium and sodium io...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: 20 April 2019Source: New Scientist, Volume 242, Issue 3226Author(s): Nic FlemingFoods and drinks fortified with protein are the latest consumer health fad. Is there any evidence that we benefit from eating more of it, asks Nic Fleming
Source: New Scientist - Category: Science Source Type: research
When my father died I lost the ability to liveSix months ago, on 9 October 2018, it was a beautiful and unusually warm day in my native city of Paris. There, in the leafy surroundings of a palliative care centre, my father took his last breath.I was there with my husband. Our three year old, playing in the room next door, was blissfully unaware of what was happening. We had been in France for five weeks and had spent a lot of time with my father. I remember thinking “this is hard, but I am strong, I’ve got this”. I helped organise his funeral, stayed with my mum a few weeks after he passed away and then f...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Mental health Psychology Depression Source Type: news
Depression is one of the most difficult conditions to contend with and manage. This is due in part to the fact that it can go undiagnosed for years. Many people suffer with depression not realizing that the problems they are having and the way they are feeling can be addressed and improved with help, time, and effort. And while anyone can suffer with depression, there are some significant differences in the way that it affects men versus women. Although there are several symptoms of depression that are common to both men and women, the way that a man experiences and expresses depression can be very different than the way a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Men's Issues Women's Issues Gender Difference Source Type: blogs
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