Initial experiences with hippocampus-sparing whole-brain radiotherapy for lung cancer patients.

Initial experiences with hippocampus-sparing whole-brain radiotherapy for lung cancer patients. Acta Oncol. 2019 Jul 15;:1-3 Authors: Nielsen M, Kristiansen C, Schytte T, Hansen O PMID: 31303085 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research

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This study aimed to identify the prognostic value of lymph node metastasis in patients with non-small cell lung cancer (NSCLC) and distant organ metastasis. A total of 42,613 NSCLC patients with distant metastasis from the surveillance, epidemiology, and end results database between 2010 and 2013 were included for analysis. The proportion of N0 stage in M1a patients was significantly higher than that in M1b patients, 34.0% and 22.7% respectively (P  
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
FINDINGSCancer that has spread to the central nervous system is notoriously difficult to treat. Now, UCLA researchers have developed a drug delivery system that breaks through the blood-brain barrier in order to reach and treat cancer that has spread to the central nervous system.In research conducted in mice, a single dose of cancer drugs in a nanoscale capsule developed by the scientists eliminated all B-cell lymphoma that had metastasized to the animals ’ central nervous system.BACKGROUNDAbout 15% to 40% of all cancers spread to the nervous system, but there are few treatment options and they only work in a small ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Zhan-Qi Cao, Zhi Wang, Ping LengAbstractNeural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment. However, aberrant expression of N-cadherin has been found in many cancers, such as lung cancer, breast cancer, prostate ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The publisher regrets Emilie Le Rhun ’s name was incorrectly written as Emilie Lerhun. The publisher would like to apologise for any inconvenience caused.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Erratum Source Type: research
This study aimed to reveal the interaction between pericytes and cancer cells. We established in vitro BBB models with rat primary cultured BBB-related cells (endothelial cells, astrocytes, and pericytes) and investigated the relationship between BBB-related cells and metastatic cancer cell lines. We observed a significant decrease in transendothelial electrical resistance with metastatic cancer cells in monolayer and coculture models with astrocytes. In contrast, the coculture model with pericytes showed inhibition of the decrease in transendothelial electrical resistance with metastatic cancer cells. In addition, the exp...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
ConclusionsTRT provided significant PFS and OS benefits in patients with oligometastatic ES-SCLC without brain or liver involved. The consolidative TRT is a reasonable treatment option for this favorable patient population.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOverall risk of cancer in our MS cohort did not significantly differ from the controls. However, the age at diagnosis of breast cancer was statistically significantly higher among the MS patients in comparison with a control population from the same patient pool. Further population-based larger studies spanning longer follow-up periods and longer exposure to emerging MS therapies are needed to evaluate cancer risk related to MS treatments and breast cancer risk in particular.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In this episode, our hosts discuss whether or not mental illness is a real disorder or if it’s just something that medical and pharmaceutical companies made up to make a profit.  SUBSCRIBE &REVIEW “Instead of taking my psychiatric medications this morning, should I have just gone to yoga?” – Michelle Hammer Highlights from ‘Mental Illness Made Up’ Episode [2:00] Is mental illness real? [4:00] Yoga doesn’t cure all mental illnesses, just like it wouldn’t cure cancer. [16:00] Dealing with people who think mental illness is not real. [19:30] Eating disorders ar...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Brain and Behavior Disorders General Source Type: blogs
Abstract BACKGROUND: A cohort of male lead-exposed workers with past blood lead levels, previously followed for mortality over 12 years, has now been followed for an additional 10 years. This has doubled the number of deaths and allowed for examination of mortality outcomes across a wide range of blood lead levels. OBJECTIVE: Evaluate association between lead exposure and 16 causes of death. METHODS: The cohort included male workers from 11 U.S. states enrolled in a U.S. lead surveillance program. Maximum blood lead level for each worker was abstracted from surveillance records. Mortality was assessed us...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
Abstract BACKGROUND: The American Society of Clinical Oncology recently recommends patients with metastatic non-small cell lung cancer (NSCLC) should be offered palliative care services earlier. We sought to investigate the timing of palliative care referral of Chinese patients with NSCLC in our center. METHOD: Retrospective medical data including demographic characteristics and referral information were collected for analysis. Overall survival (OS) was calculated as the time since cancer diagnosis till patient's death. The time interval from palliative care (PC) referral to a patient's death (PC-D) was calcu...
Source: The American Journal of Hospice and Palliative Care - Category: Palliative Care Authors: Tags: Am J Hosp Palliat Care Source Type: research
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