Study of the aqueous extract of Aloe vera and its two active components on the Wnt/β-catenin and Notch signaling pathways in colorectal cancer cells

ConclusionIn conclusion, this study showed that Aloe vera extract and its active component aloin activated the Wnt/β-catenin pathway and inhibited the Notch pathway in the presence of Wnt3a. While another active component, aloesin, activated the Wnt/β-catenin pathway and inhibited the Notch signaling pathway independent of Wnt3a. Given that Wnt/β-catenin and Notch pathway are closely associated with the progression of CRC, these findings would be helpful to better understand the colonic carcinogenicity of Aloe vera.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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This study was performed to evaluate effects of education, home visits, web, and phone counseling on chemotherapy symptoms and anxiety in patients with colorectal cancer receiving chemotherapy. This pretest-posttest, quasi-experimental study was conducted in a chemotherapy unit of a hospital between February 2014 and October 2015. Due to dropouts from the study, was completed on 51 participants in the control group and 31 participants in the experimental group. The experimental group was offered a program that includes home visit, nursing education, web counseling, and tele-counseling (HEWCOT), developed by the researchers...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
​BY ALISON BROOMFIELD​; ARJUN BHARADWAJ; KHALID MALIK, MDA 68-year-old woman was brought to the emergency department from a nursing home with a complaint of abdominal distention. The patient had no focal pain, just overall diffuse discomfort in her abdomen and upper pelvis. She and the nursing home staff did not know when her symptoms started. The patient had taken acetaminophen, but it had no effect on her discomfort.The discomfort did not radiate to her chest, back, or shoulders. The patient and nursing home indicated no recent trauma or falls, but the patient reported two episodes of non-bilious, non-bloody vomiting...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Our ancestors who lived without grains, sugars, and soft drinks enjoy predictable bowel behavior. They ate some turtle, fish, clams, mushrooms, coconut, or mongongo nuts for breakfast, and out it all came that afternoon or evening—large, steamy, filled with undigested remains and prolific quantities of bacteria, no straining, laxatives, or stack of magazines required. If instead you are living a modern life and have pancakes with maple syrup for breakfast and you’ll be lucky to pass that out by tomorrow or the next day. Or perhaps you will be constipated, not passing out your pancakes and syrup for days, passin...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates bloating bowel flora bran constipation Dr. Davis fiber grain-free grains hydrate Inflammation laxatives Opiate drugs Opiods prebiotic undoctored wheat belly Wheat Belly Total Health Source Type: blogs
Our ancestors who lived without grains, sugars, and soft drinks enjoyed predictable bowel behavior. They ate some turtle, fish, clams, mushrooms, coconut, or mongongo nuts for breakfast, and out it all came that afternoon or evening—large, steamy, filled with undigested remains and prolific quantities of bacteria, no straining, laxatives, or stack of magazines required. If instead you are living a modern life and have pancakes with maple syrup for breakfast, you’ll be lucky to pass that out by tomorrow or the next day. Or perhaps you will be constipated, not passing out your pancakes and syrup for days, passing...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates bloating bowel flora bran constipation Dr. Davis fiber grain-free grains hydrate Inflammation laxatives Opiate drugs Opiods prebiotic undoctored wheat belly Wheat Belly Total Health Source Type: blogs
Given the void in dietary wisdom due to the ineffectiveness and blunders of “official” dietary advice, there is no shortage of books or diet programs trying to fill that void, many wildly at odds with each other—paleo, Atkins, vegan, vegetarian, high-carb, low-carb, ketogenic, etc. The U.S. Dietary Guidelines for Americans, the USDA’s MyPlate and food pyramid, and organizations such as the American Heart Association and American Diabetes Association, as well as many of the diet programs in the popular press, I believe, fail to acknowledge several fundamental principles that really need to be address...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle atkins carbs Fat gluten gluten-free grains low-carb low-fat paleo protein undoctored vegan vegetarian Weight Loss Source Type: blogs
Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA-approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined. Here, we demonstrate that...
Source: Cancer Prevention Research - Category: Cancer & Oncology Authors: Tags: Research Articles Source Type: research
"The goal of Survivors Teaching Students (STS) is for future physicians, nurse practitioners, nurses and physician assistants to be able to diagnose ovarian cancer when it is in its earlier, most treatable stages. Survivors Teaching Students is offered in 96 medical schools, 103 nursing schools, 13 Nurse Practitioner schools, 26 Physician Assistant schools, and 12 allied health programs across the United States. Active programs exist in 34 states, the District of Columbia, Virgin Islands, the United Kingdom and Canada. In 2015, the program educated 10,750 students, a 10% increase over the previous year. As of June, 20...
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Cancer Communications: Poster Presentations - Proffered Abstracts Source Type: research
Conclusion: Service use resulting from toxicity-related factors occurs frequently in community oncology settings. Monitoring toxicity patterns and outcomes can inform proactive symptom management approaches to reduce toxicity burden between scheduled visits.
Source: Journal of Oncology Practice - Category: Cancer & Oncology Authors: Tags: Complications of cancer and cancer treatment, Treatment related issues, Quality, Patient safety, Quality of care, Quality of Care FOCUS ON QUALITY Source Type: research
By Stacy SimonThe US Food and Drug Administration (FDA) has approved Keytruda (pembrolizumab) to treat people with head and neck squamous cell carcinoma that has spread or come back after previous chemotherapy treatment. It’s the first immunotherapy drug approved for head and neck cancer. Keytruda is already approved for melanoma and non-small cell lung cancer.The FDA based its approval on a clinical trial of 174 people with head and neck squamous cell carcinoma that had spread or come back after they were treated with platinum-based chemotherapy. Tumors shrank or disappeared in 16% of the participants who were given...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Oral Cavity and Oropharyngeal Cancer Source Type: news
We are going to get up close and personal this month to talk about hemorrhoids. You should be familiar with these painful offenders because half to two-thirds of people between 45 and 65 will suffer from their cruelty. (Am Surg 2009;75[8]:635.) Patients may seek emergency department care if they experience bleeding or severe pain from hemorrhoids.Hemorrhoids are highly vascular structures that are round or oval in shape. They arise from the rectal and anal canal, and sometimes appear around the anus itself. It is important to note that hemorrhoids do not have arteries and veins but special blood vessels called sinusoids, c...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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